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Fig. 5 | Journal of Orthopaedic Surgery and Research

Fig. 5

From: FGD5-AS1 facilitates the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells via targeting the miR-506-3p/BMP7 axis

Fig. 5

FGD5-AS1 upregulates BMP7 via binding to miR-506-3p. A Binding sequences between BMP7 and miR-506-3p were predicted by the starBase website. B Dual-luciferase reporter assay showed the luciferase activity of BMP7-WT or BMP7-MUT in hBMSCs transfected with NC mimics or miR-506-3p mimics. C RT-qPCR analysis was used to detect the expression of BMP7 in hBMSCs transfected with NC mimics or miR-506-3p mimics. D RIP assay showed the enrichment of FGD5-AS1, miR-506-3p, and BMP7 in the anti-Ago2 group compared with the anti-IgG group. E RT-qPCR analysis showed the expression of BMP7 in hBMSCs transfected with shNC and shFGD5-AS1

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X