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Table 1 Generalities of the included studies

From: Surgical management of focal chondral defects of the knee: a Bayesian network meta-analysis

Author, year Journal Study design Follow-up (months) Treatment Procedures (n) Female (%) Mean age Mean BMI
Anders et al., 2013 [33] Open Orthop J Randomized 24 AMIC 8 12 35.0 27.4
AMIC 13 23 39.0 27.7
MFX 6 33 41.0 25.2
Bartlett et al., 2005 [16] J Bone Joint Surg Randomized 12 cACI 44 41 33.7  
mACI 47   33.4  
Basad et al., 2010 [62] Knee Surg Sports Traumatol Arthrosc Randomized 24 mACI 40 38 33.0 25.3
MFX 20 15 37.5 27.3
Becher et al., 2017 [63] J Orthop Surg Res Randomized 36 mACI 25 32 33.0 24.9
mACI 25 16 34.0 25.6
mACI 25 40 34.0 25.1
Berruto et al., 2017 [64] Injury Non-Randomized 162 pACI 9 31 31.6  
cACI 24    
Bode et al., 2013 [65] Arch Orthop Trauma Surg Non-Randomized 72 cACI 19   40.2 25.2
cACI 24   38.3 24.1
Brittberg et al., 2018 [66] Am J Sports Med Randomized 60 mACI 65 38 35.0  
MFX 63 33 34.0  
Chung et al., 2013 [32] Knee Surg Sports Traumatol Arthrosc Non-Randomized 24 MFX 12 83 44.3  
AMIC 24 42 47.4  
Cvetanovich et al., 2016 [67] Am J Sports Med Non-Randomized 24 cACI 12 22 17.0 22.8
mACI 11 22 17.0 22.8
mACI 14 22 17.0 22.8
De Girolamo et al., 2019 [68] J Clin Med Randomized 100 AMIC 12 39 30.0  
AMIC 12 40 30.0  
Ebert et al., 2015 [69] Am J Sports Med Non-Randomized 24 mACI 10 20 39.0 25.8
mACI 13 7 36.0 25.6
mACI 9 66 38.0 25.1
mACI 15 53 37.0 25.3
Ferruzzi et al., 2008 [70] J Bone Joint Surg Non-Randomized 60 pACI 48 38 32.0  
mACI 50 28 31.0  
Fossum et al., 2019 [30] Orthop J Sports Med Randomized 24 AMIC 20 60 38.3 27.9
     cACI 21 33 37.2 25.7
Gooding et al., 2006 [71] Knee Randomized 24 pACI 33 51 31.0  
cACI 35    
Gudas et al., 2006 [72] Knee Surg Sports Traumatol Arthrosc Randomized 37 MFX 28 43 24.3  
OAT 29 35 24.6  
Gudas et al., 2009 [73] J Pediatr Orthop Randomized 24 OAT 25 40 15.0  
MFX 22 40 14.0  
Gudas et al., 2012 [74] Am J Sports Med Randomized 120 OAT 28 32 25.0  
MFX 29 41 24.0  
Hoburg et al., 2019 [28] Orthop J Sports Med Non-Randomized 63 mACI 29 48 16.0 21.3
48 mACI 42 29 27.0 24.1
Horas et al., 2003 [75] J Bone Joint Surg Non-Randomized 124 pACI 20 60 31.4  
OAT 20 25 35.4  
Knutsen et al., 2016 [76] J Bone Joint Surg Randomized 180 pACI 40    
MFX 40    
Kon et al., 2009 [42] Am J Sports Med Non-Randomized 60 mACT 40 17 29.0  
MFX 40 32 31.0  
Kon et al., 2011 [43] Am J Sports Med Non-Randomized 61 mACT 22 32 46.0 24.7
58 mACI 39 35 45.0 25.6
Lim et al., 2012 [77] Clin Orthop Rel Res Randomized 60 MFX 30 40 33.0  
OAT 22 45 30.0  
pACI 18 44 25.0  
Macmull et al., 2012 [78] Int Orthop Non-Randomized 66 cACI 24 29 16.0  
mACI 7    
Macmull et al., 2012 [79] Am J Sports Med Non-Randomized 45 cACI 25 80 35.0  
35 mACI 23 61 35.0  
Niemeyer et al., 2016 [80] Am J Sports Med Randomized 12 mACI 25 33 33.0 24.9
mACI 25 16 34.0 25.6
mACI 25 40 34.0 25.1
Niemeyer et al., 2019 [27] Orthop J Sports Med Randomized 24 mACI 52 36 36.0 25.7
MFX 50 44 37.0 25.8
Saris et al., 2009 [81] Am J Sports Med Randomized 36 pACI 57 39 33.9  
MFX 61 33 33.9  
Saris et al., 2014 [82] Am J Sports Med Randomized 24 mACI 72 37 35.0 26.2
MFX 72   33.0 26.4
Schneider et al., 2016 [83] J Orthop Surg Randomized 12 MFX 13 50 47.0  
MFX 4 37.0  
Skowronski et al., 2013 [55] Orthop Traumatol Rehab Non-Randomized 60 cACI 21 42 26.0  
cACI 25 44 26.0  
Van Assche et al., 2010 [84] Knee Surg Sports Traumatol Arthrosc Randomized 24 pACI 33 33 31.0 24.0
MFX 34 10 31.0 25.0
Vanlauwe et al., 2011 [85] Am J Sports Med Randomized 60 MFX 61 20 34.0  
pACI 51 43 34.0  
Volz et al., 2017 [31] Int Orthop Randomized 60 AMIC 17 29 34.0 27.4
AMIC 17 11 39.0 27.6
MFX 13 23 40.0 25.0
Wolf et al., 2018 [86] Cartilage Non-Randomized 24 MFX 18 55 38.0  
MFX 3   50.0  
Zeifang et al., 2010 [87] Am J Sports Med Randomized 24 mACI 11 45 29.0  
pACI 10 0 30.0