Surgical management of focal chondral defects of the knee: a Bayesian network meta-analysis

Migliorini, Filippo; Eschweiler, Jörg; Schenker, Hanno; Baroncini, Alice; Tingart, Markus; Maffulli, Nicola

doi:10.1186/s13018-021-02684-z

Journal of Orthopaedic Surgery and Research

Table 1 Generalities of the included studies

From: Surgical management of focal chondral defects of the knee: a Bayesian network meta-analysis

Author, year	Journal	Study design	Follow-up (months)	Treatment	Procedures (n)	Female (%)	Mean age	Mean BMI
Anders et al., 2013 [33]	Open Orthop J	Randomized	24	AMIC	8	12	35.0	27.4
				AMIC	13	23	39.0	27.7
				MFX	6	33	41.0	25.2
Bartlett et al., 2005 [16]	J Bone Joint Surg	Randomized	12	cACI	44	41	33.7
Bartlett et al., 2005 [16]	J Bone Joint Surg	Randomized	12	mACI	47		33.4
Basad et al., 2010 [62]	Knee Surg Sports Traumatol Arthrosc	Randomized	24	mACI	40	38	33.0	25.3
Basad et al., 2010 [62]	Knee Surg Sports Traumatol Arthrosc	Randomized	24	MFX	20	15	37.5	27.3
Becher et al., 2017 [63]	J Orthop Surg Res	Randomized	36	mACI	25	32	33.0	24.9
				mACI	25	16	34.0	25.6
				mACI	25	40	34.0	25.1
Berruto et al., 2017 [64]	Injury	Non-Randomized	162	pACI	9	31	31.6
Berruto et al., 2017 [64]	Injury	Non-Randomized	162	cACI	24
Bode et al., 2013 [65]	Arch Orthop Trauma Surg	Non-Randomized	72	cACI	19		40.2	25.2
Bode et al., 2013 [65]	Arch Orthop Trauma Surg	Non-Randomized	72	cACI	24		38.3	24.1
Brittberg et al., 2018 [66]	Am J Sports Med	Randomized	60	mACI	65	38	35.0
Brittberg et al., 2018 [66]	Am J Sports Med	Randomized	60	MFX	63	33	34.0
Chung et al., 2013 [32]	Knee Surg Sports Traumatol Arthrosc	Non-Randomized	24	MFX	12	83	44.3
Chung et al., 2013 [32]	Knee Surg Sports Traumatol Arthrosc	Non-Randomized	24	AMIC	24	42	47.4
Cvetanovich et al., 2016 [67]	Am J Sports Med	Non-Randomized	24	cACI	12	22	17.0	22.8
				mACI	11	22	17.0	22.8
				mACI	14	22	17.0	22.8
De Girolamo et al., 2019 [68]	J Clin Med	Randomized	100	AMIC	12	39	30.0
De Girolamo et al., 2019 [68]	J Clin Med	Randomized	100	AMIC	12	40	30.0
Ebert et al., 2015 [69]	Am J Sports Med	Non-Randomized	24	mACI	10	20	39.0	25.8
				mACI	13	7	36.0	25.6
				mACI	9	66	38.0	25.1
				mACI	15	53	37.0	25.3
Ferruzzi et al., 2008 [70]	J Bone Joint Surg	Non-Randomized	60	pACI	48	38	32.0
Ferruzzi et al., 2008 [70]	J Bone Joint Surg	Non-Randomized	60	mACI	50	28	31.0
Fossum et al., 2019 [30]	Orthop J Sports Med	Randomized	24	AMIC	20	60	38.3	27.9
				cACI	21	33	37.2	25.7
Gooding et al., 2006 [71]	Knee	Randomized	24	pACI	33	51	31.0
Gooding et al., 2006 [71]	Knee	Randomized	24	cACI	35
Gudas et al., 2006 [72]	Knee Surg Sports Traumatol Arthrosc	Randomized	37	MFX	28	43	24.3
Gudas et al., 2006 [72]	Knee Surg Sports Traumatol Arthrosc	Randomized	37	OAT	29	35	24.6
Gudas et al., 2009 [73]	J Pediatr Orthop	Randomized	24	OAT	25	40	15.0
Gudas et al., 2009 [73]	J Pediatr Orthop	Randomized	24	MFX	22	40	14.0
Gudas et al., 2012 [74]	Am J Sports Med	Randomized	120	OAT	28	32	25.0
Gudas et al., 2012 [74]	Am J Sports Med	Randomized	120	MFX	29	41	24.0
Hoburg et al., 2019 [28]	Orthop J Sports Med	Non-Randomized	63	mACI	29	48	16.0	21.3
Hoburg et al., 2019 [28]	Orthop J Sports Med	Non-Randomized	48	mACI	42	29	27.0	24.1
Horas et al., 2003 [75]	J Bone Joint Surg	Non-Randomized	124	pACI	20	60	31.4
Horas et al., 2003 [75]	J Bone Joint Surg	Non-Randomized	124	OAT	20	25	35.4
Knutsen et al., 2016 [76]	J Bone Joint Surg	Randomized	180	pACI	40
Knutsen et al., 2016 [76]	J Bone Joint Surg	Randomized	180	MFX	40
Kon et al., 2009 [42]	Am J Sports Med	Non-Randomized	60	mACT	40	17	29.0
Kon et al., 2009 [42]	Am J Sports Med	Non-Randomized	60	MFX	40	32	31.0
Kon et al., 2011 [43]	Am J Sports Med	Non-Randomized	61	mACT	22	32	46.0	24.7
Kon et al., 2011 [43]	Am J Sports Med	Non-Randomized	58	mACI	39	35	45.0	25.6
Lim et al., 2012 [77]	Clin Orthop Rel Res	Randomized	60	MFX	30	40	33.0
				OAT	22	45	30.0
				pACI	18	44	25.0
Macmull et al., 2012 [78]	Int Orthop	Non-Randomized	66	cACI	24	29	16.0
Macmull et al., 2012 [78]	Int Orthop	Non-Randomized	66	mACI	7
Macmull et al., 2012 [79]	Am J Sports Med	Non-Randomized	45	cACI	25	80	35.0
Macmull et al., 2012 [79]	Am J Sports Med	Non-Randomized	35	mACI	23	61	35.0
Niemeyer et al., 2016 [80]	Am J Sports Med	Randomized	12	mACI	25	33	33.0	24.9
				mACI	25	16	34.0	25.6
				mACI	25	40	34.0	25.1
Niemeyer et al., 2019 [27]	Orthop J Sports Med	Randomized	24	mACI	52	36	36.0	25.7
Niemeyer et al., 2019 [27]	Orthop J Sports Med	Randomized	24	MFX	50	44	37.0	25.8
Saris et al., 2009 [81]	Am J Sports Med	Randomized	36	pACI	57	39	33.9
Saris et al., 2009 [81]	Am J Sports Med	Randomized	36	MFX	61	33	33.9
Saris et al., 2014 [82]	Am J Sports Med	Randomized	24	mACI	72	37	35.0	26.2
Saris et al., 2014 [82]	Am J Sports Med	Randomized	24	MFX	72		33.0	26.4
Schneider et al., 2016 [83]	J Orthop Surg	Randomized	12	MFX	13	50	47.0
Schneider et al., 2016 [83]	J Orthop Surg	Randomized	12	MFX	4	50	37.0
Skowronski et al., 2013 [55]	Orthop Traumatol Rehab	Non-Randomized	60	cACI	21	42	26.0
Skowronski et al., 2013 [55]	Orthop Traumatol Rehab	Non-Randomized	60	cACI	25	44	26.0
Van Assche et al., 2010 [84]	Knee Surg Sports Traumatol Arthrosc	Randomized	24	pACI	33	33	31.0	24.0
Van Assche et al., 2010 [84]	Knee Surg Sports Traumatol Arthrosc	Randomized	24	MFX	34	10	31.0	25.0
Vanlauwe et al., 2011 [85]	Am J Sports Med	Randomized	60	MFX	61	20	34.0
Vanlauwe et al., 2011 [85]	Am J Sports Med	Randomized	60	pACI	51	43	34.0
Volz et al., 2017 [31]	Int Orthop	Randomized	60	AMIC	17	29	34.0	27.4
				AMIC	17	11	39.0	27.6
				MFX	13	23	40.0	25.0
Wolf et al., 2018 [86]	Cartilage	Non-Randomized	24	MFX	18	55	38.0
Wolf et al., 2018 [86]	Cartilage	Non-Randomized	24	MFX	3		50.0
Zeifang et al., 2010 [87]	Am J Sports Med	Randomized	24	mACI	11	45	29.0
Zeifang et al., 2010 [87]	Am J Sports Med	Randomized	24	pACI	10	0	30.0

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