Table 5 The relationship between MIR17HG and MIR155HG gene polymorphism and steroid-induced ONFH subgroup analysis

 Age, > 45

rs77218221

Codominant

C/C

1 (0.4%)

0

1

0.013*

C/T

22 (9.5%)

14 (20.0%)

2.75 (1.24–6.08)

T/T

208 (90.0%)

56 (80.0%)

-

Dominant

C/C

1 (0.4%)

0

1

0.016*

C/T–T/T

230 (99.6%)

70 (100.0%)

2.65 (1.20–5.82)

Recessive

C/C–C/T

23 (10.0%)

14 (20.0%)

1

0.999

T/T

208 (90.0%)

56 (80.0%)

-

Log-additive

-

-

-

2.39 (1.12–5.08)

0.023*

 Age, > 45

rs7318578

Codominant

C/C

17 (7.4%)

10 (14.3%)

1

0.042*

C/A

90 (39.0%)

23 (32.9%)

0.82 (0.43–1.55)

A/A

121 (52.4%)

37 (52.9%)

2.62 (1.04–6.60)

Dominant

C/C

17 (7.4%)

10 (14.3%)

1

0.826

C/A–A/A

211 (91.3%)

60 (85.7%)

1.07 (0.60–1.91)

Recessive

C/C–C/A

107 (46.3%)

33 (47.1%)

1

0.022*

A/A

121 (52.4%)

37 (52.9%)

2.83 (1.61–6.92)

Log-additive

-

-

-

1.30 (0.84–2.01)

0.238

 Male

rs34904192

Codominant

A/A

24 (5.7%)

5 (4.3%)

1

0.030*

A/G

171 (40.4%)

34 (29.3%)

0.61 (0.39–0.95)

G/G

228 (53.9%)

77 (66.4%)

0.62 (0.23–1.69)

Dominant

A/A

24 (5.7%)

5 (4.3%)

1

0.024*

A/G–G/G

339 (80.1%)

111 (95.7%)

0.61 (0.40–0.94)

Recessive

A/A–A/G

195 (46.1%)

39 (33.6%)

1

0.557

G/G

228 (53.9%)

77(66.4%)

0.74 (0.27–2.00)

Log-additive

-

-

-

0.67 (0.47–0.98)

0.037*

 Female

rs11911469

Codominant

C/C

1 (1.2%)

0

1

0.034*

C/A

29 (34.9%)

17 (20.5%)

0.47 (0.23–0.94)

A/A

53 (63.9%)

66 (79.5%)

-

Dominant

C/C

1 (1.2%)

0

1

0.026*

C/A–A/A

82 (98.8%)

83 (100.0%)

0.45 (0.22–0.91)

Recessive

C/C–C/A

30 (36.1%)

17 (20.5%)

1

0.999

A/A

53 (63.9%)

66 (79.5%)

-

Log-additive

-

-

-

0.45 (0.23–0.88)

0.021*

 Course, months

rs77218221

Codominant

C/C

0

0

1

  Case, > 25

C/T

10 (7.6%)

13 (19.4%)

-

  Control, ≤ 25

T/T

122 (92.4%)

54 (80.6%)

-

Dominant

C/C

0

0

1

0.037*

C/T–T/T

132 (100.0%)

67 (100.0%)

2.64 (1.06–6.55)

Recessive

C/C–C/T

10 (7.6%)

13 (19.4%)

1

-

T/T

122 (92.4%)

54 (80.6%)

-

Log-additive

-

-

-

2.64 (1.06–6.55)

0.038*

 Course, months

rs34904192

Codominant

A/A

4 (3.0%)

7 (10.4%)

1

0.043*

  Case, > 25

A/G

43 (32.6%)

25 (37.3%)

1.22 (0.63–2.35)

  Control, ≤ 25

G/G

85 (64.4%)

35 (52.2%)

3.84 (1.04–14.15)

Dominant

A/A

4 (3.0%)

7 (10.4%)

1

0.240

A/G–G/G

128 (97.0%)

60 (89.6%)

1.45 (0.78–2.69)

Recessive

A/A–A/G

47 (35.6%)

32 (47.8%)

1

0.052

G/G

85 (64.4%)

35 (52.2%)

3.56 (0.99–12.82)

Log-additive

-

-

-

1.55 (0.95–2.55)

0.082