Fig. 3
From: Hsa_circ_0004674 promotes osteosarcoma doxorubicin resistance by regulating the miR-342-3p/FBN1 axis
Hsa_circ_0004674 sponged miR-342-3p. A The target relationship between hsa_circ_0004674 and miR-342-3p was predicted by Starbase software. Dual-luciferase reporter assay (B) and RNA pull-down assay (C) were performed to assess the interaction between hsa_circ_0004674 and miR-342-3p. D QRT-PCR was used to examine the expression of miR-342-3p in DXR-resistant OS tissues and DXR-sensitive OS tissues. E MiR-342-3p expression in DXR-resistant OS cells (U2OS_R and KHOS_R) and normal OS cells (U2OS and KHOS) was measured by qRT-PCR. F Pearson’s correlation coefficient was employed to assess the correlation between hsa_circ_0004674 and miR-342-3p in OS tissues. *P < 0.05