Ref. | First Author | Country | Year | Size(E/C) | Design | Procedures | tTXA Regimen | Qualitya |
---|---|---|---|---|---|---|---|---|
20 | Claus | Norway | 2003 | 16/14 | RCT | Operations for low back pain | 500 mg TXA added into 50 ml 0.9% NS | 7 |
21 | Hoshang | Iran | 2010 | 50/50 | RCT | One/two level laminectomy | 250 mg TXA added into 5 ml 0.9% NS | 8 |
22 | Liang | China | 2016 | 30/30 | RCT | Multilevel posterior lumbar degenerative procedures | 2000 mg TXA (in 20 ml 0.9% NS) soaked Gelfoam (100 cm2) | 7 |
29 | Ren | China | 2017 | 50/50 | nRCT | Posterior lumbar spinal fusion surgery | 1 g TXA added into 100 ml 0.9% NS | 7 |
30 | Zhinan | China | 2017 | 50/50 | nRCT | Posterior lumbar spinal fusion surgery | 1 g TXA added into 100 ml 0.9% NS | 7 |
23 | Xu | China | 2017 | 40/40 | RCT | Total laminectomy with pedicle screw instrumentation | 1 g TXA added into 100 ml 0.9% NS | 8 |
24 | Mu | China | 2019 | 39/42 | RCT | Posterior lumbar interbody fusion | 1 g TXA (in 50 ml 0.9% NS) soaked gelatin sponge | 7 |
25 | Wood | USA | 2018 | 12/17 | RCT | Spinal surgery | 3 g TXA irrigated in the wound prior to closure | 7 |
31 | Liang | China | 2020 | 20/20 | nRCT | Posterior lumbar decompression and fusion | 1 ampoule (10% transamin, 10 ml, 1000 mg TXA; Daiichi-Sankyo, Tokyo, Japan) | 7 |
26 | Weera | Thailand | 2019 | 29/28 | RCT | Long-segment instrumented fusion without decompression | 1 g TXA added into 20 ml 0.9% NS | 7 |
27 | Xu | China | 2020 | 30/30 | RCT | Posterior lumbar interbody fusion | 1 g TXA added into 100 ml 0.9% NS | 7 |
32 | Weera | Thailand | 2018 | 35/38 | nRCT | Long-segment instrumented fusion without decompression | 1 g TXA added into 20 ml 0.9% NS | 7 |
28 | Han | China | 2019 | 48/24 | RCT | Multilevel thoracolumbar bone graft fusion and internal fixation | 500 mg/1000 mg TXA added into 100 ml 0.9% NS | 7 |