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Table 1 Characteristics of studies included

From: Tranexamic acid given into wound reduces postoperative drainage, blood loss, and hospital stay in spinal surgeries: a meta-analysis

Ref. First Author Country Year Size(E/C) Design Procedures tTXA Regimen Qualitya
20 Claus Norway 2003 16/14 RCT Operations for low back pain 500 mg TXA added into 50 ml 0.9% NS 7
21 Hoshang Iran 2010 50/50 RCT One/two level laminectomy 250 mg TXA added into 5 ml 0.9% NS 8
22 Liang China 2016 30/30 RCT Multilevel posterior lumbar degenerative procedures 2000 mg TXA (in 20 ml 0.9% NS) soaked Gelfoam (100 cm2) 7
29 Ren China 2017 50/50 nRCT Posterior lumbar spinal fusion surgery 1 g TXA added into 100 ml 0.9% NS 7
30 Zhinan China 2017 50/50 nRCT Posterior lumbar spinal fusion surgery 1 g TXA added into 100 ml 0.9% NS 7
23 Xu China 2017 40/40 RCT Total laminectomy with pedicle screw instrumentation 1 g TXA added into 100 ml 0.9% NS 8
24 Mu China 2019 39/42 RCT Posterior lumbar interbody fusion 1 g TXA (in 50 ml 0.9% NS) soaked gelatin sponge 7
25 Wood USA 2018 12/17 RCT Spinal surgery 3 g TXA irrigated in the wound prior to closure 7
31 Liang China 2020 20/20 nRCT Posterior lumbar decompression and fusion 1 ampoule (10% transamin, 10 ml, 1000 mg TXA; Daiichi-Sankyo, Tokyo, Japan) 7
26 Weera Thailand 2019 29/28 RCT Long-segment instrumented fusion without decompression 1 g TXA added into 20 ml 0.9% NS 7
27 Xu China 2020 30/30 RCT Posterior lumbar interbody fusion 1 g TXA added into 100 ml 0.9% NS 7
32 Weera Thailand 2018 35/38 nRCT Long-segment instrumented fusion without decompression 1 g TXA added into 20 ml 0.9% NS 7
28 Han China 2019 48/24 RCT Multilevel thoracolumbar bone graft fusion and internal fixation 500 mg/1000 mg TXA added into 100 ml 0.9% NS 7
  1. Ref., reference; E/C, experimental group/control group; RCT, randomized control trial; nRCT, non-randomized control trial; tXA, topical use of tranexamic acid. a Study quality assessed using the Newcastle-Ottawa Scale (NOS)