Table 1 Characteristics of the included studies

Study (Published year)

Inclusion interval

Country

No. of patients

Male/Female

Mean Age (y) (range)

Study design/type

Time between FDG administration and scanning(min)

Yaǧci-Küpeli et al. [10]

2014.07-2014.12

Turkey

63

43/20

8.7 (2-17)

RCohort

60

Zapata et al. [11]

2009.01-2014.10

USA

69

32/37

9.6 (0.5-21)

RCohort

60

Cistaro et al. [12]

NR

Italy

224

NR

14 (4-18)

RCohort

60-90

Chen et al. [13]

2010.05-2017.02

China

93

66/27

8 (1-21)

RCohort

60

Badr et al. [14]

2010.02-2015.12

Egypt

140

105/35

8.6 (2-17)

RCohort

45-60

Hassan et al. [15]

2010.07-2015.06

Pakistan

784

653/131

10.3 (2-18)

RCohort

60

Agrawal et al. [16]

NR

India

38

30/8

9.8 (3-18)

RCohort

45-60

Purz et al. [17]

2002-2006

Germany

175

89/86

14.6

PCohort

40-90

Cheng et al. [18]

2007.07-2008.12

USA

54

26/28

14.8 (6-24)

RCohort

60-90

Study (Published year)

Interval between FDG-PET/CT and BMB

FDG dose

Criteria for positivity

Yaǧci-Küpeli et al, [10]

NR

185 MBq

Bone marrow uptake was higher than the liver

Zapata et al, [11]

NR

NR

FDG avidity was equal to primary tumor or greater than adjacent tissues

Cistaro et al, [12]

<15 days

weight-adapted^a

isolated/multiple focal uptake was higher than the liver or spleen^b

Chen et al, [13]

1-14 days

5.18 MBq/Kg

Focal or multifocal abnormally increased FDG uptake

Badr et al, [14]

<14 days

5 to 10 MBq/kg,

Bone marrow uptake was higher than the liver

Hassan et al, [15]

<14 days

weight-based (90–270 MBq)

one or more bifocal uptake^b

Agrawal et al, [16]

NR

3.7 MBq/kg

focal uptake was higher than the liver^b

Purz et al, [17]

NR

weight–adapted

isolated/multiple focal uptake was higher than the liver

Cheng et al, [18]

NR

5.18 MBq/kg or 0.14 mCi/kg

focal or multifocal abnormally increased FDG uptake