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Table 1 Characteristics of the included studies

From: FDG-PET/CT versus bone marrow biopsy in bone marrow involvement in newly diagnosed paediatric lymphoma: a systematic review and meta-analysis

Study (Published year) Inclusion interval Country No. of patients Male/Female Mean Age (y) (range) Study design/type Time between FDG administration and scanning(min)
Yaǧci-Küpeli et al. [10] 2014.07-2014.12 Turkey 63 43/20 8.7 (2-17) RCohort 60
Zapata et al. [11] 2009.01-2014.10 USA 69 32/37 9.6 (0.5-21) RCohort 60
Cistaro et al. [12] NR Italy 224 NR 14 (4-18) RCohort 60-90
Chen et al. [13] 2010.05-2017.02 China 93 66/27 8 (1-21) RCohort 60
Badr et al. [14] 2010.02-2015.12 Egypt 140 105/35 8.6 (2-17) RCohort 45-60
Hassan et al. [15] 2010.07-2015.06 Pakistan 784 653/131 10.3 (2-18) RCohort 60
Agrawal et al. [16] NR India 38 30/8 9.8 (3-18) RCohort 45-60
Purz et al. [17] 2002-2006 Germany 175 89/86 14.6 PCohort 40-90
Cheng et al. [18] 2007.07-2008.12 USA 54 26/28 14.8 (6-24) RCohort 60-90
Study (Published year) Interval between FDG-PET/CT and BMB FDG dose Criteria for positivity Reference standard Lymphoma type
Yaǧci-Küpeli et al, [10] NR 185 MBq Bone marrow uptake was higher than the liver BMB; PET/CT; follow-up HL and NH
Zapata et al, [11] NR NR FDG avidity was equal to primary tumor or greater than adjacent tissues BMB; PET/CT; follow-up HL and NHL
Cistaro et al, [12] <15 days weight-adapteda isolated/multiple focal uptake was higher than the liver or spleenb BMB; PET/CT; follow-up HL
Chen et al, [13] 1-14 days 5.18 MBq/Kg Focal or multifocal abnormally increased FDG uptake BMB; PET/CT; follow-up; MRI NHL
Badr et al, [14] <14 days 5 to 10 MBq/kg, Bone marrow uptake was higher than the liver BMB; PET/CT; followup; MRI HL and NHL
Hassan et al, [15] <14 days weight-based (90–270 MBq) one or more bifocal uptakeb BMB; PET/CT; follow-up HL
Agrawal et al, [16] NR 3.7 MBq/kg focal uptake was higher than the liverb BMB; PET/CT; follow-up HL
Purz et al, [17] NR weight–adapted isolated/multiple focal uptake was higher than the liver BMB; PET/CT; follow-up HL
Cheng et al, [18] NR 5.18 MBq/kg or 0.14 mCi/kg focal or multifocal abnormally increased FDG uptake BMB; PET/CT; follow-up HL and NHL
  1. P prospective, R retrospective, NR not reported, BMB bone marrow biopsy, CT computed tomography, FDG 18F-fluoro-2-deoxy-D-glucose, PET positron emission tomography, BMI bone marrow involvement, MRI magnetic resonance imaging
  2. a Weight-adapted FDG dosage recommended according to the manufacturer guidelines for each scan model
  3. b Diffusely/homogeneously increased bone marrow FDG uptake was also regarded as positive for BMI