Table 2 The genotypes and allele frequencies of SOX4 gene rs79958549, rs139085828, rs201335371, and osteoporosis susceptibility
From: The effect of SOX4 gene 3′UTR polymorphisms on osteoporosis
Case(n = 330) | Control(n = 330) | HWE P | OR (95% CI)* | P | |
|---|---|---|---|---|---|
rs79958549 | |||||
GG | 265(80.30%) | 312(94.55%) | 0.15 | 1.00(reference) | |
GA | 39(11.82%) | 17(5.15%) | 2.70(1.49–4.89) | < 0.01 | |
AA | 26(7.88%) | 1(0.30%) | 2.10(4.13–2.18) | < 0.01 | |
GA + AA vs. GG | 4.25(2.46–7.35) | < 0.01 | |||
AA vs. GG + GA | 2.01(1.63–2.09) | < 0.01 | |||
GG vs. AA | 1.18(0.94–1.47) | 0.17 | |||
G | 569(86.21%) | 641(97.12%) | 1.00(reference) | ||
A | 91(13.79%) | 19(2.88%) | 5.40(3.25–8.96) | < 0.01 | |
rs139085828 | |||||
GG | 281(85.15%) | 314(95.15%) | 0.09 | 1.00(reference) | |
GA | 29(8.79%) | 15(4.55%) | 2.16(1.14–4.11) | 0.03 | |
AA | 20(6.06%) | 1(0.30%) | 2.02(1.55–2.12) | < 0.01 | |
GA + AA vs. GG | 1.60(1.31–1.83) | < 0.01 | |||
AA vs. GG + GA | 1.96(1.51–2.06) | < 0.01 | |||
GG vs. AA | 1.06(0.94–1.19) | 0.36 | |||
G | 591(89.55%) | 643(97.42%) | 1.00(reference) | ||
A | 69(10.45%) | 17(2.58%) | 1.68(1.45–1.85) | < 0.01 | |
rs201335371 | |||||
CC | 186(56.36%) | 121(36.67%) | 0.09 | 1.00(reference) | |
CT | 105(31.82%) | 145(43.94%) | 0.47(0.34–0.66) | < 0.01 | |
TT | 39(11.82%) | 64(19.39%) | 0.40(0.25–0.63) | < 0.01 | |
CT + TT vs. CC | 0.45(0.33–0.61) | < 0.01 | |||
TT vs. CC + CT | 0.56(0.36–0.86) | 0.01 | |||
CC vs. TT | 0.65(0.49–0.86) | < 0.01 | |||
C | 477(72.27%) | 387(58.64%) | 1.00(reference) | ||
T | 183(27.73%) | 273(41.36%) | 0.54(0.43–0.69) | < 0.01 |