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Fig. 4 | Journal of Orthopaedic Surgery and Research

Fig. 4

From: Potential role of m6A RNA methylation regulators in osteosarcoma and its clinical prognostic value

Fig. 4

Survival curve analysis, GSEA analysis, and validation in GEO dataset of two survival-related regulatory factors. a FTO survival curve. b IGF2BP2 survival curve. c, e GESA analysis of samples with high FTO expression (a total of 7 enriched pathways were screened out for histogram). d GESA analysis of IGF2BP2 high expression samples (histogram of the top 15 pathways ranked by P value from small to large by screening the enriched pathways). e, f Select the top 6 pathway (ranked from small to large by p value) to make the distribution curve of enrich score. The vertical axis represents the ES value of this pathway. Positive ES indicates upregulated activity of this pathway, and negative ES indicates downregulated activity of this pathway. g–i The GEO dataset was used to verify the characteristics of IGF2BP2. g PCA analysis of data. h, i Survival curves of the samples are divided into two categories according to the median value and the mean value

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