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Table 6 Analysis of the relationship between OPG/RANKL/RANK methylation and ONFH risk induced by alcohol in men

From: OPG/RANKL/RANK gene methylation among alcohol-induced femoral head necrosis in northern Chinese men

Gene

OR

95% CI

p

OPG3_CpG_5

0.36

0.14–0.91

0.031*

OPG4_CpG_13

2.64

1.11–6.62

0.028*

OPG5_CpG_1

2.34

1.04–5.25

0.040*

OPG5_CpG_4.5

3.92

1.59–9.63

0.003**

OPG5_CpG_10

2.65

1.16–6.04

0.020*

OPG5_CpG_11

3.62

1.58–8.33

0.002**

RANK1_CpG_10.11

2.38

1.04–5.45

0.039*

RANK1_CpG_12.13.14

2.95

1.15–7.56

0.024*

RANK1_CpG_17

2.39

1.04–5.47

0.04*

RANK1_CpG_24.25.26.27

0.13

0.03–0.62

0.011*

RANK2_CpG_7.8

0.15

0.04–0.56

0.005**

RANK2_CpG_16

3.87

1.64–9.14

0.002**

RANK2_CpG_18

3.26

1.38–7.70

0.007**

RANK2_CpG_29

2.73

1.19–6.28

0.018*

RANK3_CpG_10

3.76

1.61–8.83

0.002**

RANKL1_CpG_4

3.12

1.31–7.46

0.010*

RANKL2_CpG_2

2.62

1.06–6.48

0.037*

RANKL2_CpG_12.13

3.01

1.31–6.92

0.009**

RANKL2_CpG_16.17

3.11

1.36–7.1

0.007**

RANKL2_CpG_21

3.55

1.50–8.41

0.004**

RANKL2_CpG_25.26.27

2.55

1.12–5.79

0.026*

RANKL2_CpG_46

3.39

1.45–7.90

0.005**

RANKL5_CpG_1

2.84

1.21–6..67

0.017*

  1. p value adjusted for age was calculated by logistic regression
  2. OR odds ratio, CI confidence interval
  3. *p < 0.05
  4. **p < 0.01