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Fig. 3 | Journal of Orthopaedic Surgery and Research

Fig. 3

From: Mesenchymal stem cell-originated exosomal lncRNA HAND2-AS1 impairs rheumatoid arthritis fibroblast-like synoviocyte activation through miR-143-3p/TNFAIP3/NF-κB pathway

Fig. 3

MiR-143-3p reverses the effects of HAND2-AS1 overexpression on RA-FLSs. a qRT-PCR analysis of miR-143-3p expression in MH7A cells transfected with miR-NC or miR-143-3p. b–g MH7A cells were transfected with vector + miR-NC, HAND2-AS1 + miR-NC, or HAND2-AS1 + miR-143-3p. b CCK-8 assay for cell proliferation. c Flow cytometry for cell apoptosis. d Wound healing assay for cell migration. e Transwell assay for cell invasion. f ELISA for the detection of IL-6 and TNF-α levels in cells. g Measurement of p-p65 and p65 levels in cell using Western blot. **P < 0.001, ***P < 0.0001

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X