Variants in RETN gene are associated with steroid-induced osteonecrosis of the femoral head risk among Han Chinese people

Table 3 Analysis of the association between SNPs of RETN gene and steroid-induced ONFH risk

SNP ID	Model	Genotype	Control	Case	OR (95% CI)	p value
rs34861192	Codominant	GG	130	146	1
		AG	61	52	0.76(0.49–1.18)	0.220
		AA	9	1	0.10(0.01–0.79)	0.029*
	Dominant	GG	130	146	1
	Dominant	AG-AA	70	53	0.67(0.44–1.03)	0.071
	Recessive	GG-AG	191	198	1
	Recessive	AA	9	1	0.11(0.01–0.85)	0.035*
	Log-additive	–	–	–	0.63(0.43–0.93)	0.019*
rs3219175	Codominant	GG	129	146	1
		AG	62	50	0.71(0.46–1.11)	0.133
		AA	9	1	0.10(0.01–0.79)	0.029*
	Dominant	GG	129	146	1
	Dominant	AG-AA	71	51	0.63(0.41–0.98)	0.038*
	Recessive	GG-AG	191	196	1
	Recessive	AA	9	1	0.11(0.01–0.86)	0.036*
	Log-additive	–	–	–	0.60(0.41–0.88)	0.010*
rs3745368	Codominant	GG	137	156	1
		AG	56	41	0.64(0.40–1.02)	0.059
		AA	6	2	0.29(0.06–1.45)	0.131
	Dominant	GG	137	156	1
	Dominant	AG-AA	62	43	0.61(0.38–0.95)	0.030*
	Recessive	GG-AG	193	197	1
	Recessive	AA	6	2	0.32(0.06–1.63)	0.170
	Log-additive	–	–	–	0.61(0.41–0.92)	0.019*
rs1477341	Codominant	TT	51	68	1
		AT	105	90	0.64(0.41–1.02)	0.059
		AA	43	32	0.56(0.31–1.00)	0.051
	Dominant	TT	51	68	1
	Dominant	AT-AA	148	122	0.62(0.40–0.96)	0.030*
	Recessive	TT-AT	156	158	1
	Recessive	AA	43	32	0.74(0.44–1.23)	0.239
	Log-additive	–	–	–	0.73(0.55–0.98)	0.036*

SNP single-nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval
p value adjusted for age was calculated by logistic regression
Italicized values are statistically significant
*p < 0.05 indicates statistical significance

ISSN: 1749-799X