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Fig. 6 | Journal of Orthopaedic Surgery and Research

Fig. 6

From: Mesenchymal stem cells genetically engineered to express platelet-derived growth factor and heme oxygenase-1 ameliorate osteoarthritis in a canine model

Fig. 6

Gene expression of LPS-stimulated synovial cells when co-cultured with MSCs, PDGF-MSCs, or HO-1-MSCs. a, b Pro-inflammatory factor expression after 24 and 72 h of incubation. c, d Collagen degradation markers. e, f Expression of aggrecan degradation markers (ADAMTS-4 and ADAMTS-5) and pain-related marker (NGF). g, h Expression of anti-degradation factors. Data are shown as fold change compared to chondrocytes alone. *P < 0.05 and **P < 0.01 compared to the control. #P < 0.05 and ##P < 0.01 compared to the LPS group. P < 0.05 and ††P < 0.01, a significant difference between the indicated groups

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