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Table 1 Characteristics of the included studies

From: Reliability of circulating fibrinogen in the diagnosis of prosthesis-related infections: a systematic review and meta-analysis

Author

Study type

Mean age (range, years)

Gender

BMI

Participants

Detection method

Level range (N/PJI)

Threshold value

Gold standard

N-PJI

PJI

F

M

N-PJI

PJI

N-PJI

PJI

N-PJI

PJI

Xu et al. 2020 [25]

R

NV

NV

NV

NV

NV

NV

207

153

NV

2.96 ± 0.79

4.18 ± 1.16

3.57 g/L

ICM

Klim et al. 2020 [24]

P

65.1 ± 14.6

65.7 ± 15.8

46

38

NV

NV

29

55

Coagulometry with sodium citrate blood

NV

NV

515 mg/dL

MSIS

Xu et al. 2019 [16, 22]

R

NV

53.3 ± 14.9

56

46

25.3 ± 3.5

24.6 ± 4.0

94

8

STA-R Evolution analyzer

NV

NV

3.61 g/L

ICM

Wu et al. 2020 [18]

R

69.13 ± 11.19

62.64 ± 11.58

68

41

24.49 ± 5.87

24.75 ± 3.90

76

33

NV

3.01 ± 0.72

4.81 ± 1.87

3.61 g/L

ICM

Li et al. 2019 [21]

R, M

61.3 (23–86)

63.7 (18–89)

NV

NV

25.15 (14.93–46.66)

25.01 (16.71–33.06)

363

76

STA-R Evolution analyzer or Sysmex CS-5100 System

NV

NV

4.01 g/L

ICM

Wang et al. 2020 [17, 27]

R

63.4 (23–87)

64.6 (37–82)

87

70

NV

NV

106

51

NV

NV

NV

3.56 g/L

ICM

Bin et al. 2020 [23]

R

60.30 ± 13.79

62.13 ± 11.37

52

38

23.62 ± 3.67

23.72 ± 4.26

37

53

NV

2.86 (2.46–3.25)

4.37 (3.82–4.95)

3.60 g/L

ICM

  1. PJI peri-prosthetic joint infection, N-PJI not periprosthetic joint infection, BMI body mass index, P prospective study, R retrospective study, M multicenter study, F female, M male, NA not applicable, MSIS Musculoskeletal Infection Society, ICM Internal Consensus Meeting