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Table 1 Characteristics of the included studies

From: Reliability of circulating fibrinogen in the diagnosis of prosthesis-related infections: a systematic review and meta-analysis

Author Study type Mean age (range, years) Gender BMI Participants Detection method Level range (N/PJI) Threshold value Gold standard
N-PJI PJI F M N-PJI PJI N-PJI PJI N-PJI PJI
Xu et al. 2020 [25] R NV NV NV NV NV NV 207 153 NV 2.96 ± 0.79 4.18 ± 1.16 3.57 g/L ICM
Klim et al. 2020 [24] P 65.1 ± 14.6 65.7 ± 15.8 46 38 NV NV 29 55 Coagulometry with sodium citrate blood NV NV 515 mg/dL MSIS
Xu et al. 2019 [16, 22] R NV 53.3 ± 14.9 56 46 25.3 ± 3.5 24.6 ± 4.0 94 8 STA-R Evolution analyzer NV NV 3.61 g/L ICM
Wu et al. 2020 [18] R 69.13 ± 11.19 62.64 ± 11.58 68 41 24.49 ± 5.87 24.75 ± 3.90 76 33 NV 3.01 ± 0.72 4.81 ± 1.87 3.61 g/L ICM
Li et al. 2019 [21] R, M 61.3 (23–86) 63.7 (18–89) NV NV 25.15 (14.93–46.66) 25.01 (16.71–33.06) 363 76 STA-R Evolution analyzer or Sysmex CS-5100 System NV NV 4.01 g/L ICM
Wang et al. 2020 [17, 27] R 63.4 (23–87) 64.6 (37–82) 87 70 NV NV 106 51 NV NV NV 3.56 g/L ICM
Bin et al. 2020 [23] R 60.30 ± 13.79 62.13 ± 11.37 52 38 23.62 ± 3.67 23.72 ± 4.26 37 53 NV 2.86 (2.46–3.25) 4.37 (3.82–4.95) 3.60 g/L ICM
  1. PJI peri-prosthetic joint infection, N-PJI not periprosthetic joint infection, BMI body mass index, P prospective study, R retrospective study, M multicenter study, F female, M male, NA not applicable, MSIS Musculoskeletal Infection Society, ICM Internal Consensus Meeting