Potential risk factors | No. of studies | Pooled ORs or SMDs | 95% CI | p value | I2 |
---|---|---|---|---|---|
Age | 15 | 0.43a | (0.24, 0.61) | < 0.001 | 73.4% |
11 | 1.15 | (1.08, 1.22) | < 0.001 | 63.5% | |
Female (compared with male) | 14 | 0.91 | (0.82, 1.18) | 0.851 | 49.0% |
BMI | 7 | − 0.22a | (− 0.55, 0.12) | 0.207 | 81.4% |
Education (years) | 6 | − 0.18a | (− 0.35, − 0.02) | 0.026 | 0.0% |
MMSE | 11 | − 0.32a | (− 0.52, − 0.13) | 0.001 | 57.1% |
Cognitive impairment | 3 | 6.84 | (3.27, 14.33) | < 0.001 | 0.0% |
Dementia | 5 | 3.09 | (2.10, 4.56) | < 0.001 | 38.6% |
Neurological disorders | 5 | 2.26 | (1.23, 4.15) | < 0.001 | 0.0% |
Psychiatric illness | 2 | 2.74 | (1.34, 5.62) | 0.006 | 0.0% |
Obstructive sleep apnea | 2 | 4.17 | (1.72, 10.09) | 0.002 | 0.0% |
Knee replacement | 6 | 1.42 | (1.00, 2.02) | 0.048 | 9.8% |
Duration of surgery | 7 | 0.29a | (0.06, 0.52) | 0.013 | 57.4% |
Blood loss | 4 | 0.30a | (0.15, 0.44) | < 0.001 | 0.0% |
Spinal anesthesia (compared with general) | 5 | 0.62 | (0.46, 0.85) | 0.003 | 45.7% |
History of cerebrovascular events | 4 | 2.51 | (1.28, 4.91) | 0.007 | 58.4% |
ASA ≥ 3 | 8 | 1.59 | (1.25, 2.03) | < 0.001 | 29.3% |
CCI | 5 | 0.35a | (0.04, 0.66) | 0.029 | 56.9% |
Length of stay | 6 | 0.53a | (0.20, 0.87) | 0.002 | 56.7% |
Total protein | 2 | − 0.68a | (− 0.87, − 0.48) | < 0.001 | 0.0% |
Albumin | 2 | − 0.77a | (− 1.36, − 0.19) | 0.009 | 71.6% |
Hemoglobin | 6 | − 0.58a | (− 1.11, − 0.04) | 0.034 | 94.4% |
Creatine | 3 | 0.16a | (− 0.00, 0.32) | 0.051 | 0.0% |
C-Reactive protein | 2 | 0.76a | (− 0.88, 2.41) | 0.363 | 96.2% |
Blood glucose | 2 | 0.41a | (− 0.67, 1.51) | 0.463 | 91.7% |
Alcohol abuse | 3 | 0.69 | (0.32, 1.46) | 0.329 | 76.7% |
Diabetic mellitus | 8 | 1.09 | (0.86, 1.40) | 0.476 | 29.7% |
Hypertension | 7 | 1.06 | (0.88, 1.29) | 0.522 | 0.0% |
Pulmonary disorders | 3 | 1.13 | (0.70, 1.82) | 0.61 | 0.0% |
Tobacco usage | 3 | 1.22 | (0.68, 2.19) | 0.507 | 0.0% |