Fig. 2

miR-107 overexpression alleviates the effects of LPS/ATP induction on chondrocytes. a miR-107 expression in chondrocytes treated with LPS and ATP after transfection was analyzed by RT-qPCR analysis. ***P < 0.001 vs. control group. ^###P < 0.001 vs. mimic NC group. ^∆∆∆P < 0.001 vs. miR-107 mimic-#1 group. b The proliferation of chondrocytes treated with LPS and ATP after transfection was detected by CCK-8 assay. ***P < 0.001 vs. control group. ^###P < 0.001 vs. LPS + ATP group. ^∆∆∆P < 0.001 vs. LPS + ATP + mimic NC group. c The expression of Col II in supernatant of chondrocytes treated with LPS and ATP after transfection was detected by Col II ELISA assay. **P < 0.01 and ***P < 0.001 vs. control group. ^###P < 0.001 vs. LPS + ATP group. ^∆∆∆P < 0.001 vs. LPS + ATP + mimic NC group. d The expression of IL-1β in supernatant of chondrocytes treated with LPS and ATP after transfection was detected by IL-1β ELISA assay. ***P < 0.001 vs. control group. ^###P < 0.001 vs. LPS + ATP group. ^∆∆∆P < 0.001 vs. LPS + ATP + mimic NC group. e The expression of IL-18 in supernatant of chondrocytes treated with LPS and ATP after transfection was detected by IL-18 ELISA assay. ***P < 0.001 vs. control group. ^###P < 0.001 vs. LPS + ATP group. ^∆∆∆P < 0.001 vs. LPS + ATP + mimic NC group. f The expression of MMP-13 in supernatant of chondrocytes treated with LPS and ATP after transfection was detected by MMP-13 ELISA assay. **P < 0.01 and ***P < 0.001 vs. control group. ^###P < 0.001 vs. LPS + ATP group. ^∆∆∆P < 0.001 vs. LPS + ATP + mimic NC group