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Table 3 Methods of administration and operation

From: Intra-articular vs. intravenous administration: a meta-analysis of tranexamic acid in primary total knee arthroplasty

Study IV dosage IA dosage Type of operation Surgical approach
Jules-Elysee et al. [14] 1 g TXA × two doses; POPO 3 g TXA × one dose; before tourniquet release Primary unilateral TKA Unclear
Laoruengthana et al. [13] 10 mg/kg TXA × one dose; IO 15 mg/kg TXA × one dose; before closure Primary unilateral TKA Medial parapatellar
Zhang et al. [15, 52] 20 mg/kg TXA × one dose; PEO 3 g TXA × one dose; after closure Primary unilateral TKA Medial parapatellar
Abdel et al. [20] 1 g TXA × one dose; PEO 3 g TXA × one dose; after cemented Primary unilateral TKA Medial parapatellar or midvastus approach
Ahmed et al. [17] 1.5 g TXA × one dose; PTO 1.5 g TXA × one dose; while closure Primary simultaneous bilateral TKA Unclear
López-Hualda et al. [21] 1 g TXA × one dose; PEO 1 g TXA × one dose; after closure Primary unilateral TKA Medial parapatellar
George et al. [16] 10 mg/kg TXA × two doses; POPO 1.5 g TXA × one dose; before closure Primary unilateral TKA Medial parapatellar
Subramanyam et al. [19] 10 mg/kg TXA × one dose; PEO 1.5 g TXA × one dose; after closure Primary unilateral TKA Medial parapatellar
Wei et al. [18] 10 mg/kg TXA × one dose; PEO 1 g TXA × one dose; before tourniquet release Primary unilateral TKA Unclear
Goyal et al. [36] 1 g TXA × three doses; IO/PTO/PTO 3 g TXA × one dose; after closure Primary unilateral TKA Medial parapatellar
Lacko et al. [22] 10 mg/kg TXA × two doses; POPO 3 g TXA × one dose; after cemented Primary unilateral TKA Medial parapatellar
Maniar et al. [33] 10 mg/kg TXA × two doses (bilateral); IO 3 g TXA × two doses(bilateral); after cemented Primary simultaneous bilateral TKA Midvastus approach
10 mg/kg TXA × three doses; POIOPO
Prakash et al. [26] 10 mg/kg TXA × three doses; POIOPO 3 g TXA × one dose; before closure Primary unilateral TKA Medial parapatellar
Song et al. [35] 10 mg/kg TXA × three doses; POIOPO 1.5 g TXA × one dose; after closure Primary bilateral TKA Medial parapatellar
Stowers et al. [24] 1 g TXA × one dose; IO 1 g TXA × one dose; after closure Primary unilateral TKA Medial parapatellar
Uğurlu et al. [34] 20 mg/kg TXA × one dose; PEO 3 g TXA × one dose; after closure Primary unilateral TKA Medial parapatellar
Wang et al. [11, 23] 1 g TXA × one dose; IO 1 g TXA × one dose; before closure Primary unilateral TKA Medial parapatellar
Zekcer et al. [25] 20 mg/kg TXA × one dose; unclear 1.5 g TXA × one dose; before tourniquet release Primary unilateral TKA Unclear
Aggarwal et al. [39] 15 mg/kg TXA × two dose; IOPO 15 mg/kg TXA × one dose; before closure Primary simultaneous bilateral TKA Medial parapatellar
Chen et al. [29, 53] 1.5 g TXA × one dose; IO 1.5 g TXA × one dose; after cemented Primary unilateral TKA Medial parapatellar
Drosos et al. [38] 1 g TXA × one dose; PEO 1 g TXA × one dose; before closure Primary unilateral TKA Medial parapatellar
Keyhani et al. [42] 0.5 g TXA × one dose; IO 1.5 g TXA × two doses; before/after closure Primary unilateral TKA Medial parapatellar
May et al. [37] 1 g TXA × two doses; POPO 2 g TXA × one dose; after closure Primary unilateral TKA Unclear
Pinsornsak et al. [37] 0.75 mg TXA × one dose; IO 0.75 mg × one dose; before tourniquet release Primary unilateral TKA Medial parapatellar
Tzatzairis et al. [40] 1 g TXA × one dose; PEO 1 g TXA × one dose; after closure Primary unilateral TKA Medial parapatellar
Aguilera et al. [43] 1 g TXA × two doses; POIO 1 g TXA × one dose; after cemented Primary unilateral TKA Medial parapatellar
Digas et al. [44] 15 mg/kg TXA × one dose; IO 2 g TXA × one dose; after closure Primary unilateral TKA Medial parapatellar
Öztaş et al. [45] 15 mg/kg TXA × two doses; POPO
10 mg/kg TXA × one dose; 1-h infusion
2 g TXA × one dose; before tourniquet release Primary unilateral TKA Unclear
Gomez-Barrena et al. [46] 15 mg/kg TXA × two doses; IOPO 3 g TXA × one dose; before + after closure Primary unilateral TKA Medial parapatellar
Patel et al. [47] 10 mg/kg TXA × one dose; IO 2 g TXA × one dose; before tourniquet release Primary unilateral TKA Medial or subvastus parapatellar
Sarzaeem et al. [48] 1.5 g TXA × one dose; PTO 1.5 g TXA × one dose; after closure Primary unilateral TKA Subvastus approach
3 g TXA × one dose; before closure
Soni et al. [49] 10 mg/kg TXA × three doses; POIOPO 3 g TXA × one dose; before tourniquet release Primary unilateral TKA Midvastus approach
Seo et al. [50] 1.5 g TXA × one dose; PTO 1.5 g TXA × one dose; while closure Primary unilateral TKA Medial parapatellar
Maniar et al. [51] 10 mg/kg TXA × one dose; IO 3 g TXA × one dose; before tourniquet release Primary unilateral TKA Midvastus approach
10 mg/kg TXA × two doses; IOPO
10 mg/kg TXA × two doses; POIO
10 mg/kg TXA × three doses; POIOPO
  1. IO intraoperative dose, IOPO intra- and postoperative doses, PEO preoperative dose, POIO pre- and intraoperative doses, POIOPO all three doses, POPO pre- and postoperative doses, PTO postoperative dose, TXA tranexamic acid