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Table 2 Univariable meta-regression and subgroup analysis for potential heterogeneity in studies for D-dimer

From: Fibrinogen performs better than D-dimer for the diagnosis of periprosthetic joint infection: a meta-analysis of diagnostic trials

Covariate No. of studies Sensitivity (95% CI) P value Specificity (95% CI) P value
Country
 USA 2 0.82 [0.69–0.95] 0.27 0.86 [0.75–0.97] 0.90
 China 7 0.79 [0.71–0.87] . 0.73 [0.64–0.82] .
Study design
 Prospective 3 0.89 [0.83–0.95] 0.41 0.84 [0.75–0.94] 0.71
 Retrospective 6 0.73 [0.67–0.79] . 0.72 [0.61–0.82] .
No. of involved joints
 > 150 3 0.76 [0.64–0.87] 0.01* 0.74 [0.58–0.89] 0.14
 < 150 6 0.81 [0.74–0.89] . 0.78 [0.68–0.88] .
Disease spectrum
 PJI + aseptic 6 0.79 [0.70–0.87] 0.06 0.73 [0.62–0.84] 0.03*
 PJI + aseptic + primary arthroplasty/reimplantaion 3 0.81 [0.69–0.92] . 0.82 [0.71–0.93] .
Comorbidities influencing D-dimer
 Excluded 5 0.77 [0.67–0.86] 0.01* 0.71 [0.59–0.82] 0.01*
 Not excluded 4 0.82 [0.73–0.91] . 0.83 [0.73–0.92] .
Sample source      
 Plasma 4 0.75 [0.65–0.85] 0.00* 0.68 [0.56–0.81] 0.00*
 Serum 5 0.83 [0.75–0.90] . 0.82 [0.74–0.90] .
Optimal cutoff value
 < 900 ng/ml 4 0.81 [0.71–0.91] 0.14 0.81 [0.72–0.91] 0.54
 > 900 ng/ml 5 0.78 [0.69–0.87] . 0.72 [0.60–0.83] .
  1. *Statistical significance (p < 0.05)