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Table 1 Characteristics of included studies

From: Fibrinogen performs better than D-dimer for the diagnosis of periprosthetic joint infection: a meta-analysis of diagnostic trials

Study Country Study design Gender (F/M) Age (years ± SD) Involved joints (PJI/total) Sites of arthroplasty Disease spectrum Comorbidities * Cutoff
D-dimer
Qin et al. [11] China P 69/53 65.21 ± 10.51 55/122 Hips and knees Chronic PJI + aseptic Excluded 1170 ng/ml
Xiong et al. [13] China P 48/32 61.60 ± 12.22 26/80 Hips and knees PJI + aseptic Excluded 756 ng/ml
Shahi et al. [12] USA P 94/101 62.46 57/195 Hips and knees Primary arthroplasty + PJI + aseptic + reimplantation Not excluded 850 ng/mL
Xu et al. [14] China R NM NM 82/224 Hips and knees PJI + aseptic Excluded 1020 ng/mL
Huang et al. [8] China R 46/34 67.15 ± 2.64 31/101 Hips and knees Primary arthroplasty + PJI + aseptic Excluded 850 ng/mL
Pannu et al. [10] USA R 62/49 68.89 ± 10 49/111 Hips and knees PJI + aseptic NM 2300 ng/mL
Hu et al. [7] China R 41/36 63.08 40/77 Hips and knees, 2 others PJI + aseptic Not excluded 955 ng/ml
Li et al. [15] China R NM NM 76/439 Hips and knees PJI + aseptic Excluded 1250 ng/ml
Wu et al. [17] China R 82/54 66.32 ± 11.73 35/116 Hips and knees PJI + aseptic+reimplantation Not excluded 410 ng/ml
Fibrinogen
Li et al. [15] China R NM NM 76/439 Hips and knees PJI + aseptic Excluded 4.01 g/L
Wu et al. [17] China R 82/54 66.32 ± 11.73 35/116 Hips and knees PJI + aseptic+reimplantation Not excluded 3.61 g/L
Klim et al. [16] Austria P NM 65.50 ± 15.31 78/124 Hips and knees PJI + aseptic Excluded 5.19 g/L
Xu et al. [9] China R NM NM 153/360 Hips and knees PJI + aseptic Excluded 3.57 g/L
  1. NM not mentioned, PJI periprosthetic joint infection, P perspective, R retrospective
  2. *Comorbidities referred to comorbidities influencing D-dimer or fibrinogen