Table 1 The information of included studies
Study | Country | H/K | Placebo | TXA | TXA administration |
|---|---|---|---|---|---|
Wang et al. 2018 [18] | China | K | 0 | Once:50 Twice:50 Thrice:50 Quartic:50 | Once: 2 g at 2 h pre-operatively Twice: 2 g at 2 h pre-operatively and 1 g at 3 h post-operatively Thrice: 2 g at 2 h pre-operatively and 1 g at 3 and 9 h post-operatively Quartic: 2 g at 2 h pre-operatively and 1 g at 3, 9, and 15 h post-operatively |
Wang et al. (H1) 2019 [19] | China | H | 0 | Once:50 Twice:50 Thrice:50 Quartic:50 | Once: 2 g at 2 h pre-operatively Twice: 2 g at 2 h pre-operatively and 1 g at 3 h post-operatively Thrice: 2 g at 2 h pre-operatively and 1 g at 3 and 9 h post-operatively Quartic:2 g at 2 h pre-operatively and 1 g at 3, 9, and 15 h post-operatively |
Tang et al. 2019 [16] | China | K | 0 | Once:50 Twice:50 Quartic:51 | Once: 2 g at 2 h pre-operatively Twice: 2 g at 2 h pre-operatively and 4 h post-operatively Quartic: 2 g at 2 h pre-operatively and 4, 10, and 16 h post-operatively |
Wang et al. (H2) 2019 [20] | China | H | 60 | Twice:60 Thrice:60 Quartic:60 Quintic:60 | Twice: 2 g at 2 h pre-operatively and 1 g at 3 h post-operatively Thrice: 2 g at 2 h pre-operatively and 1 g at 3 and 7 h post-operatively Quartic: 2 g at 2 h pre-operatively and 1 g at 3, 7, and 11 h post-operatively Quintic: 2 g at 2 h pre-operatively and 1 g at 3, 7, 11, and 15 h post-operatively |
Wang et al. 2019 [17] | China | K | 55 | Twice:55 Thrice:55 Quartic:55 Quintic:55 | Twice: 2 g at 2 h pre-operatively and 1 g at 3 h post-operatively Thrice: 2 g at 2 h pre-operatively and 1 g at 3 and 7 h post-operatively Quartic: 2 g at 2 h pre-operatively and 1 g at 3, 7, and 11 h post-operatively Quintic: 2 g at 2 h pre-operatively and 1 g at 3, 7, 11, and 15 h post-operatively |
Cao et al. 2019 [15] | China | H | 0 | Once:51 Twice:51 Quartic:50 | Once: 2 g at 2 h pre-operatively Twice: 2 g at 2 h pre-operatively and 4 h post-operatively Quartic: 2 g at 2 h pre-operatively and 4, 10, and 16 h post-operatively |
Yuan et al. 2017 [21] | China | K | 140 | Twice:140 | Twice: 2 mg/kg at 2 h pre-operatively and 12 h post-operatively |
Zhao et al. 2018 [22] | China | H | 40 | Twice:40 | Twice: 2 mg/kg at 2 h pre-operatively and 3 h post-operatively |
Zohar et al. 2004 [23] | China | K | 20 | Quartic:20 | Quartic: 1 g at 1 h pre-operatively and 6, 12, and 18 h post-operatively |