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Table 1 Basic characteristic of the studies included in the meta-analysis

From: Mid- to long-term rates of symptomatic adjacent-level disease requiring surgery after cervical total disc replacement compared with anterior cervical discectomy and fusion: a meta-analysis of prospective randomized clinical trials

Study Study design Sample size Follow-up time Prosthesis Operative level Follow-up rate Study center
TDR ACDF TDR ACDF
Garrido et al. (2010) [24] RCT 21 26 48 months Bryan 1 85.7% 76.9% Single
Burkus et al. (2010) [28] RCT 276 265 60 months Prestige ST 1 52.2% 47.9% Multiple
Delamarter et al. (2013) [27] RCT 103 106 60 months Prodisc C 1 72.7% 63.5% Multiple
Phillips et al. (2015) [32] RCT 218 185 84 months PCM 1 31.2% 22.7% Multiple
Hou et al. (2016) [30] RCT 56 51 61 months Mobi-C 1 91.1% 94.1% Single
Hisey et al. (2016) [29] RCT 164 81 60 months Mobi-C 1 85.5% 78.9% Multiple
Donk et al. (2017) RCT 50 47 8.9 ± 1.9 years Bryan 1 98.0% 97.9% Single
Radcliff et al. (2017) [33] RCT 164 81 84 months Mobi-C 1 80.1% 74.3% Multiple
RCT 225 105 84 months Mobi-C 2 84.4% 75.0% Multiple
Ghobrial et al. (2018) [34] RCT 518 486 84 months Bryan/Prestige ST 1 Not specified Not specified Mutiple
RCT 242 221 120 months Bryan 1 53.7% 46.6% Mutiple
  1. TDR cervical total disc replacement, ACDF anterior cervical discectomy and fusion, RCT randomized controlled trial