Mid- to long-term rates of symptomatic adjacent-level disease requiring surgery after cervical total disc replacement compared with anterior cervical discectomy and fusion: a meta-analysis of prospective randomized clinical trials

Table 1 Basic characteristic of the studies included in the meta-analysis

Study	Study design	Sample size		Follow-up time	Prosthesis	Operative level	Follow-up rate		Study center
Study	Study design	TDR	ACDF	Follow-up time	Prosthesis	Operative level	TDR	ACDF	Study center
Garrido et al. (2010) [24]	RCT	21	26	48 months	Bryan	1	85.7%	76.9%	Single
Burkus et al. (2010) [28]	RCT	276	265	60 months	Prestige ST	1	52.2%	47.9%	Multiple
Delamarter et al. (2013) [27]	RCT	103	106	60 months	Prodisc C	1	72.7%	63.5%	Multiple
Phillips et al. (2015) [32]	RCT	218	185	84 months	PCM	1	31.2%	22.7%	Multiple
Hou et al. (2016) [30]	RCT	56	51	61 months	Mobi-C	1	91.1%	94.1%	Single
Hisey et al. (2016) [29]	RCT	164	81	60 months	Mobi-C	1	85.5%	78.9%	Multiple
Donk et al. (2017)	RCT	50	47	8.9 ± 1.9 years	Bryan	1	98.0%	97.9%	Single
Radcliff et al. (2017) [33]	RCT	164	81	84 months	Mobi-C	1	80.1%	74.3%	Multiple
Radcliff et al. (2017) [33]	RCT	225	105	84 months	Mobi-C	2	84.4%	75.0%	Multiple
Ghobrial et al. (2018) [34]	RCT	518	486	84 months	Bryan/Prestige ST	1	Not specified	Not specified	Mutiple
Ghobrial et al. (2018) [34]	RCT	242	221	120 months	Bryan	1	53.7%	46.6%	Mutiple

TDR cervical total disc replacement, ACDF anterior cervical discectomy and fusion, RCT randomized controlled trial

ISSN: 1749-799X