Table 2 The top 5 BP, CC, and MF enrichment analyses of the upregulated and downregulated DEGs

BP

GO:0001501

Skeletal system development

12/81

1.55E−06

0.003

COL1A2/PAPSS1/GJA1/COL3A1/TIMP1/LUM/CTSK/MGP/PPIB/PLS3/SPARC/TGFBI

12

BP

GO:0042176

Regulation of protein catabolic process

10/81

4.33E−06

0.004

GSK3A/MSN/EEF1A1/GJA1/GPX1/TIMP1/CLU/NDUFA13/CDK5RAP3/PTTG1IP

10

BP

GO:0030198

Extracellular matrix organization

9/81

1.96E−05

0.013

COL1A2/COL3A1/TIMP1/LUM/COL5A2/CTSK/FN1/HTRA1/SPARC

9

BP

GO:0030199

Collagen fibril organization

4/81

5.02E−05

0.021

COL1A2/COL3A1/LUM/COL5A2

4

BP

GO:0043062

Extracellular structure organization

9/81

6.18E−05

0.021

COL1A2/COL3A1/TIMP1/LUM/COL5A2/CTSK/FN1/HTRA1/SPARC

9

BP

GO:0030168

Platelet activation

6/81

6.50E−05

0.021

ACTB/COL1A2/NOS3/COL3A1/ACTG1/CLIC1

6

CC

GO:0062023

Collagen-containing extracellular matrix

17/84

1.98E−12

5.40E−10

COL1A2/PCOLCE/ASPN/LGALS1/COL3A1/TIMP1/THBS2/LUM/COL5A2/MGP/MXRA5/S100A4/FN1/CLU/HTRA1/SPARC/TGFBI

17

CC

GO:0031012

Extracellular matrix

17/84

2.47E−11

3.37E−09

COL1A2/PCOLCE/ASPN/LGALS1/COL3A1/TIMP1/THBS2/LUM/COL5A2/MGP/MXRA5/S100A4/FN1/CLU/HTRA1/SPARC/TGFBI

17

CC

GO:0005583

Fibrillar collagen trimer

4/84

1.23E−07

8.37E−06

COL1A2/COL3A1/LUM/COL5A2

4

CC

GO:0098643

Banded collagen fibril

4/84

1.23E−07

8.37E−06

COL1A2/COL3A1/LUM/COL5A2

4

CC

GO:0098644

Complex of collagen trimers

4/84

1.11E−06

6.06E−05

COL1A2/COL3A1/LUM/COL5A2

4

MF

GO:0005201

Extracellular matrix structural constituent

12/80

9.73E−12

2.35E−09

COL1A2/PCOLCE/ASPN/COL3A1/THBS2/LUM/COL5A2/MGP/MXRA5/FN1/SPARC/TGFBI

12

MF

GO:0005518

Collagen binding

8/80

4.10E−10

4.97E−08

PCOLCE/ASPN/LUM/CTSK/PPIB/FN1/SPARC/TGFBI

8

MF

GO:0097718

Disordered domain-specific binding

3/80

0.000412372

0.033

GJA1/FN1/GAPDH

3

MF

GO:0030020

Extracellular matrix structural constituent conferring tensile strength

3/80

0.000945361

0.037

COL1A2/COL3A1/COL5A2

3

MF

GO:0099186

Structural constituent of post-synapse

2/80

0.000963809

0.037

ACTB/ACTG1

2

KEGG

hsa05205

Proteoglycans in cancer

8/50

3.50E−05

0.004

ACTB/COL1A2/MSN/CD63/LUM/FN1/ACTG1/RPS6

8

KEGG

hsa04611

Platelet activation

5/50

0.001031369

0.059

ACTB/COL1A2/NOS3/COL3A1/ACTG1

5

KEGG

hsa04151

PI3K-Akt signaling pathway

8/50

0.001491165

0.059

YWHAB/COL1A2/SGK1/NOS3/THBS2/FN1/RPS6/CHRM1

8

KEGG

hsa04810

Regulation of actin cytoskeleton

6/50

0.00205303

0.061

ACTB/MSN/PFN2/FN1/ACTG1/CHRM1

6

KEGG

hsa04714

Thermogenesis

6/50

0.003083363

0.069

ACTB/ACTG1/NDUFA13/RPS6/ND2/UQCRH

6