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Table 2 Characteristics of the included studies for meta-analysis

From: Meta-analysis of serum and/or plasma D-dimer in the diagnosis of periprosthetic joint infection

Study

Country

Enrolment period

Total cases

Infected cases

Study design

Location

Cut-off (ng/mL)

Sen

Spe

Standard

Received antibiotics

Exclusion criteria

Inclusion criteria

Acquisition time

[13]

USA

From April 2015 to August 2016

195

57

Prospective study

Hip, knee

850

89.47%

92.75%

ICM criteria (2014)

Yes

1, 9, 10, 11, 13

2, 15

The day of surgery

[17]

China

From October 2016 to October 2017

30

15

Prospective study

Hip, knee

850

66.67%

60.00%

MSIS criteria (2011)

NA

3, 4, 12, 15

 

Before surgery

[15]

China

From June 2016 to December 2018

101

31

Retrospective study

Hip, knee

850

71%

80%

ICM criteria (2014)

NA

1, 2, 4, 9, 10, 11, 13, 15

 

Before surgery

[25]

China

From January 2016 to December 2017

439

76

Retrospective study (multicentre)

Hip, knee

1250

64.5%

65%

ICM criteria (2014)

NA

2, 4, 5, 6, 15

 

The day of admission

[18]

China

From April 2017 to August 2018

80

26

Prospective study

Hip, knee

756

80.77%

79.63%

MSIS criteria (2011)

NA

1, 5, 9, 11, 15

 

The day before surgery

[24]

China

From January 2013 to December 2018

318

129

Retrospective Study

Hip, knee

1020

68.29%

50.70%

ICM criteria (2014)

Yes

8, 9, 14

2, 4, 5, 7, 15

The day of admission

[16]

China

From January 2015 to December 2018

122

55

Prospective study

Hip, knee

1170

92.73%

74.63%

ICM criteria (2014)

NA

3, 4, 5, 7, 11, 13, 15

 

The day before surgery

  1. Sen sensitivity, Spe specificity, ICM International Consensus Meeting, MSIS Musculoskeletal Infection Society, NA Not available