Skip to main content

Table 4 Univariate and multivariate analysis of overall survival rates

From: Influence of marital status on overall survival in adult patients with chordoma: a SEER-based study

Characteristic

Univariate analysis

Multivariate analysis

Hazard ratio (95% CI)

p value

Hazard ratio (95% CI)

p value

Age at diagnosis

 

< 0.001

 

< 0.001

 < 40

Reference

 

Reference

 

 40–60

1.92 (1.40–2.64)

< 0.001

1.97 (1.42–2.73)

< 0.001

 > 60

4.83 (3.57–6.53)

< 0.001

4.28 (3.08–5.96)

< 0.001

Sex

    

 Male

Reference

 

Reference

 

 Female

0.86 (0.71–1.04)

0.109

0.82 (0.67–1.00)

0.048

Marital status

 

< 0.001

 

0.006

 Married

Reference

 

Reference

 

 Divorced/separated

1.29 (0.92–1.80)

0.136

1.42 (1.01–1.99)

0.046

 Widowed

2.82 (2.13–3.73)

< 0.001

1.71 (1.25–2.33)

< 0.001

 Single

0.83 (0.64–1.09)

0.175

1.16 (0.88–1.53)

0.303

Primary site

 

< 0.001

 

0.181

 Bones of skull and face and associated joints

Reference

 

Reference

 

 Vertebral column

1.93 (1.52–2.44)

< 0.001

1.19 (0.92–1.54)

0.196

 Pelvic bone, sacrum, coccyx, and associated joints

1.94 (1.54–2.44)

< 0.001

0.97 (0.73–1.28)

0.809

Disease stage

 

< 0.001

 

< 0.001

 Localized

Reference

 

Reference

 

 Regional

1.41 (1.13–1.75)

0.002

1.43 (1.15–1.79)

0.002

 Distant

2.22 (1.62–3.05)

< 0.001

2.31 (1.66–3.20)

< 0.001

 Unstaged

1.68 (1.24–2.29)

0.001

1.17 (0.85–1.62)

0.327

Tumor size

 

< 0.001

 

< 0.001

 < 5 cm

Reference

 

Reference

 

 5–10 cm

1.96 (1.47–2.61)

< 0.001

1.25 (0.91–1.71)

0.173

 > 10 cm

2.98 (2.08–4.27)

< 0.001

1.85 (1.22–2.80)

0.004

 Unknown

2.04 (1.57–2.65)

< 0.001

1.50 (1.13–1.98)

0.005

Histological type

 

0.004

 

0.124

 Conventional chordoma

Reference

 

Reference

 

 Chondroid chordoma

0.52 (0.29–0.92)

0.025

0.78 (0.43–1.42)

0.419

 Dedifferentiated chordoma

3.03 (1.25–7.32)

0.014

2.11 (0.83–5.35)

0.115

Surgery

 

< 0.001

 

< 0.001

 Surgery not performed

Reference

 

Reference

 

 STR

0.39 (0.30–0.52)

< 0.001

0.58 (0.44–0.76)

< 0.001

 GTR

0.35 (0.26–0.46)

< 0.001

0.41 (0.30–0.55)

< 0.001

 Unknown extent of resection

0.82 (0.63–1.07)

0.144

0.95 (0.71–1.26)

0.723

Radiotherapy

    

 Yes

Reference

 

Reference

 

 No

0.97 (0.80–1.16)

0.709

1.07 (0.89–1.30)

0.466

Chemotherapy

    

 Yes

Reference

 

Reference

 

 No

0.51 (0.34–0.76)

0.001

0.71 (0.47–1.09)

0.120

  1. Abbreviations: STR subtotal resection, GTR gross total/radical resection
Back to article page

Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X