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Table 3 Characteristics of included studies

From: D-dimer in the diagnosis of periprosthetic joint infection: a systematic review and meta-analysis

Study

Year

Country

Study design

No. of patientsa

Mean age

Mal/female

Site of arthroplasty

Exclusion criteria

Reference standard

Cut-off

Sample

Shahi et al. [20]

2017

USA

Prospective

57/245b

61.5

129/116

Knee (98) and hip (97)

A

MSIS

850 ng/ml

Serum

Fu et al. [22]

2019

China

Prospective

15/45

65.8

12/33

Knee (40) and hip (5)

B

MSIS

850 ng/ml

Plasma

Li et al. [19]

2019

China

Retrospective

95/565

61.7

248/317

Knee (153) and hip (412)

A

ICM

1250 ng/ml

Plasma

Xu et al. [18]

2019

China

Retrospective

129/318

NA

NA

Knee (63) and hip (23)

A

MSIS

1020 ng/ml

Plasma

Huang et al. [21]

2019

China

Retrospective

31/101

66.4

NA

Hip (101)

B

MSIS

850 ng/ml

Serum

Qin et al. [16]

2020

China

Prospective

55/122

65.2

53/69

Knee (44) and hip (78)

B

MSIS

1170 ng/ml

Serum

Xiong et al. [17]

2019

China

Prospective

26/80

62.3

32/48

Knee (47) and hip (33)

B

MSIS

760 ng/ml

Serum

Pannu et al. [23]

2020

USA

Retrospective

49/111

68.9

49/111

Knee (69) and hip (42)

A

ICM

850 ng/ml

serum

  1. A does not exclude patients with rheumatoid arthritis, autoimmune diseases, tumors, smoking and obesity; B exclude patients with rheumatoid arthritis, autoimmune diseases, tumors, smoking, and obesity
  2. NA not available
  3. aThe values are given as the number of patients with an infection/total number of patients in study
  4. b50 of 245 patients were extra-articular infection