Fig. 4

IHC of healing bone. BMP-6 in skeleton muscles (labeled as ‘m’), periosteum (as ‘p’), marrow and woven bone (as ‘w’) inside the callus. Positive spots were also found scattered in osteocytes (as ‘oc’) and extracellular matrix in cortex (as ‘c’). Fewer BMP-6 immunoreactive materials were detected in the cortex of the bone of the diabetic animals (f, g, h), compared with the non-diabetic ones (c, d, e)