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Table 4 Significantly upregulated genes in both bone and kidney (GZZSZTW vs. Blank)

From: Deciphering the potential pharmaceutical mechanism of Guzhi Zengsheng Zhitongwan on rat bone and kidney based on the “kidney governing bone” theory

Gene name

Bone

Kidney

Blank (FPKM)

GZZSZTW (FPKM)

log2 fold change (GZZSZTW/Blank)

p value

Blank (FPKM)

GZZSZTW (FPKM)

log2 fold change (GZZSZTW/Blank)

p value

Cation channel sperm-associated protein 2 (Catsper2)

0.51

2.63

2.37

2.02E−06

1.68

3.96

1.24

2.67E−05

Period circadian protein homolog 3 (Per3)

1.39

4.17

1.58

3.29E−05

2.19

6.66

1.60

4.74E−18

Schlafen family member 12-like (Slfn12l)

38.51

264.68

2.78

0

1.29

2.62

1.02

4.83E−06

Minor histocompatibility protein HA-1 (Hmha1)

26.16

74.34

1.51

4.20E−138

1.40

2.93

1.07

9.10E−06

Transcription factor jun-B (Junb)

13.65

36.86

1.43

4.01E−30

18.24

51.84

1.51

3.68E−60

Cadherin-23 (Cdh23)

0.19

0.83

2.13

1.45E−08

0.09

0.71

2.98

9.60E−14

Fetuin-B (Fetub)

0.93

4.99

2.42

1.73E−07

2.63

7.66

1.54

6.98E−10

Protocadherin gamma-A11 (Pcdhga11)

0.01

0.48

5.58

3.61E−05

0.10

0.70

2.81

6.73E−06

Protein BANP (Banp)

4.52

13.57

1.59

1.40E−18

3.91

9.66

1.30

5.39E−15

Protein phosphatase 1 regulatory subunit 1A (Ppp1r1a)

0.46

2.52

2.45

9.74E−05

174.26

401.40

1.20

1.34E−274

Beta-enolase (Eno3)

5.72

32.64

2.51

4.42E−44

1.82

4.82

1.41

1.12E−04

Ankyrin repeat domain-containing protein 13D (Ankrd13d)

1.40

3.55

1.34

2.71E−04

0.43

1.71

1.99

1.22E−04

Autophagy-related protein 16-2 (Atg16l2)

4.13

9.46

1.20

3.16E−08

1.05

2.71

1.37

1.85E−04

B cell lymphoma 6 protein homolog (Bcl6)

3.50

8.67

1.31

9.91E−13

3.06

6.38

1.06

1.39E−09

Proto-oncogene c-Fos (Fos)

5.47

12.82

1.23

2.31E−12

0.75

10.37

3.79

7.87E−31