Table 1 The results of GO function analysis for downregulated miRNAs

hsa-miR-1202

GO:0070412 R-SMAD binding

1.09E−02

1

LDLRAD4

hsa-miR-1202

GO:0008066 glutamate receptor activity

1.28E−02

1

GRM4

hsa-miR-1202

GO:0035035 histone acetyltransferase binding

1.28E−02

1

ETS1

hsa-miR-1202

GO:0070063 RNA polymerase binding

1.75E−02

1

PPIB

hsa-miR-1202

GO:0003755 peptidyl-prolyl cis-trans isomerase activity

2.04E−02

1

PPIB

hsa-miR-1202

GO:0016859 cis-trans isomerase activity

2.13E−02

1

PPIB

hsa-miR-1202

GO:0005518 collagen binding

3.16E−02

1

PPIB

hsa-miR-1202

GO:0046332 SMAD binding

3.30E−02

1

LDLRAD4

hsa-miR-1202

GO:0051082 unfolded protein binding

4.73E−02

1

PPIB

hsa-miR-33b-3p

GO:0003774 motor activity

4.55E−03

2

MYO3A/SMC1A

hsa-miR-33b-3p

GO:0019215 intermediate filament binding

1.01E−02

1

SYNM

hsa-miR-33b-3p

GO:0030898 actin-dependent ATPase activity

1.01E−02

1

MYO3A

hsa-miR-33b-3p

GO:0034236 protein kinase A catalytic subunit binding

1.16E−02

1

PRKAR1A

hsa-miR-33b-3p

GO:0000146 microfilament motor activity

1.70E−02

1

MYO3A

hsa-miR-33b-3p

GO:0001221 transcription cofactor binding

1.70E−02

1

RORA

hsa-miR-33b-3p

GO:0030552 cAMP binding

1.85E−02

1

PRKAR1A

hsa-miR-33b-3p

GO:0030291 protein serine/threonine kinase inhibitor activity

2.23E−02

1

PRKAR1A

hsa-miR-33b-3p

GO:0043531 ADP binding

2.53E−02

1

MYO3A

hsa-miR-33b-3p

GO:0030551 cyclic nucleotide binding

2.76E−02

1

PRKAR1A

hsa-miR-33b-3p

GO:0005484 SNAP receptor activity

2.91E−02

1

STX16

hsa-miR-33b-3p

GO:0008307 structural constituent of muscle

3.06E−02

1

SYNM

hsa-miR-33b-3p

GO:0051018 protein kinase A binding

3.21E−02

1

PRKAR1A

hsa-miR-33b-3p

GO:0032934 sterol binding

3.29E−02

1

RORA

hsa-miR-33b-3p

GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding

3.74E−02

1

RORA

hsa-miR-33b-3p

GO:0015296 anion:cation symporter activity

3.74E−02

1

SLC12A7

hsa-miR-33b-3p

GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding

3.74E−02

1

RORA

hsa-miR-33b-3p

GO:0003707 steroid hormone receptor activity

4.41E−02

1

RORA

hsa-miR-33b-3p

GO:0003682 chromatin binding

4.85E−02

2

POU2F1/SMC1A

hsa-miR-4281

GO:0005337 nucleoside transmembrane transporter activity

3.10E−03

1

SLC29A2

hsa-miR-4281

GO:0015932 nucleobase-containing compound transmembrane transporter activity

6.91E−03

1

SLC29A2

hsa-miR-4281

GO:1901505 carbohydrate derivative transporter activity

7.15E−03

1

SLC29A2

hsa-miR-4281

GO:0030674 protein binding, bridging

3.63E−02

1

BCL3

hsa-miR-4281

GO:0060090 binding, bridging

4.00E−02

1

BCL3

hsa-miR-4284

GO:0004114 3′,5′-cyclic-nucleotide phosphodiesterase activity

1.64E−03

2

PDE4C/PDE11A

hsa-miR-4284

GO:0004112 cyclic-nucleotide phosphodiesterase activity

1.78E−03

2

PDE4C/PDE11A