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Table 1 The results of GO function analysis for downregulated miRNAs

From: MicroRNA-1202 plays a vital role in osteoarthritis via KCNQ1OT1 has-miR-1202-ETS1 regulatory pathway

ClusterGOP valueCountSymbol
hsa-miR-1202GO:0070412 R-SMAD binding1.09E−021LDLRAD4
hsa-miR-1202GO:0008066 glutamate receptor activity1.28E−021GRM4
hsa-miR-1202GO:0035035 histone acetyltransferase binding1.28E−021ETS1
hsa-miR-1202GO:0070063 RNA polymerase binding1.75E−021PPIB
hsa-miR-1202GO:0003755 peptidyl-prolyl cis-trans isomerase activity2.04E−021PPIB
hsa-miR-1202GO:0016859 cis-trans isomerase activity2.13E−021PPIB
hsa-miR-1202GO:0005518 collagen binding3.16E−021PPIB
hsa-miR-1202GO:0046332 SMAD binding3.30E−021LDLRAD4
hsa-miR-1202GO:0051082 unfolded protein binding4.73E−021PPIB
hsa-miR-33b-3pGO:0003774 motor activity4.55E−032MYO3A/SMC1A
hsa-miR-33b-3pGO:0019215 intermediate filament binding1.01E−021SYNM
hsa-miR-33b-3pGO:0030898 actin-dependent ATPase activity1.01E−021MYO3A
hsa-miR-33b-3pGO:0034236 protein kinase A catalytic subunit binding1.16E−021PRKAR1A
hsa-miR-33b-3pGO:0000146 microfilament motor activity1.70E−021MYO3A
hsa-miR-33b-3pGO:0001221 transcription cofactor binding1.70E−021RORA
hsa-miR-33b-3pGO:0030552 cAMP binding1.85E−021PRKAR1A
hsa-miR-33b-3pGO:0030291 protein serine/threonine kinase inhibitor activity2.23E−021PRKAR1A
hsa-miR-33b-3pGO:0043531 ADP binding2.53E−021MYO3A
hsa-miR-33b-3pGO:0030551 cyclic nucleotide binding2.76E−021PRKAR1A
hsa-miR-33b-3pGO:0005484 SNAP receptor activity2.91E−021STX16
hsa-miR-33b-3pGO:0008307 structural constituent of muscle3.06E−021SYNM
hsa-miR-33b-3pGO:0051018 protein kinase A binding3.21E−021PRKAR1A
hsa-miR-33b-3pGO:0032934 sterol binding3.29E−021RORA
hsa-miR-33b-3pGO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding3.74E−021RORA
hsa-miR-33b-3pGO:0015296 anion:cation symporter activity3.74E−021SLC12A7
hsa-miR-33b-3pGO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding3.74E−021RORA
hsa-miR-33b-3pGO:0003707 steroid hormone receptor activity4.41E−021RORA
hsa-miR-33b-3pGO:0003682 chromatin binding4.85E−022POU2F1/SMC1A
hsa-miR-4281GO:0005337 nucleoside transmembrane transporter activity3.10E−031SLC29A2
hsa-miR-4281GO:0015932 nucleobase-containing compound transmembrane transporter activity6.91E−031SLC29A2
hsa-miR-4281GO:1901505 carbohydrate derivative transporter activity7.15E−031SLC29A2
hsa-miR-4281GO:0030674 protein binding, bridging3.63E−021BCL3
hsa-miR-4281GO:0060090 binding, bridging4.00E−021BCL3
hsa-miR-4284GO:0004114 3′,5′-cyclic-nucleotide phosphodiesterase activity1.64E−032PDE4C/PDE11A
hsa-miR-4284GO:0004112 cyclic-nucleotide phosphodiesterase activity1.78E−032PDE4C/PDE11A
  1. GO Gene Ontology; P < 0.05 was considered to be significantly different