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Table 7 Comparison of key characteristics of this pilot study with other studies on treatment of subjects suffering from sPTRCT with stem cells published in the literature

From: Safety and efficacy of treating symptomatic, partial-thickness rotator cuff tears with fresh, uncultured, unmodified, autologous adipose-derived regenerative cells (UA-ADRCs) isolated at the point of care: a prospective, randomized, controlled first-in-human pilot study

Reference characteristic

This study

[52]

[53]

[54]

[55]

[56]

Use of stem cells as the sole therapy

Yes

No

No

No

No

Yes

Number of subjects in the treatment group

11

14

45

8

35

13

Control group

Yes

No

No

No

Yes

Noa

Number of subjects in the control group

5

n/a

n/a

n/a

35

3+3

RCT

Yes

No

No

No

No

No

Statistical analysis of differences between and/or within groups as result of treatment

Yes (b/w)

No

Yes (w)

No

Yes (b/w)

Yes (w)

Augmentation of rotator cuff repair with stem cells

No

Yes

Yes

Yes

Yes

No

Arthroscopic evaluation of the rotator cuff before injection of stem cells

No

n/a

n/a

n/a

n/a

Yes

Use of UA-ADRCs (1), ASCs (2) or BM-MSCs (3)

1

3

3

3

1

2

  1. RCT randomized controlled trial; UA-ADRCs fresh, uncultured, unmodified, autologous adipose derived regenerative cells; ASCs adipose-derived stem cells; BM-MSCs bone marrow-derived mesenchymal stem cells
  2. aDifferent groups of subjects with different doses of ASCs, but no other control group