Fig. 4

JNK inhibitor suppresses MMP-3 in both MH7A cells and RA-FLS. a(1) An illustrative Western blot picture of MMP-3 following SP600125 treatment (15 and 30 μM) after 3 and 24 h in MH7A cells. a(2) Normalized intensities were graphed (N = 3). Normalization was performed with MMP-3 band intensity of untreated MH7A cell (3-h incubation). All values are expressed as the mean ± SEM (N = 3). The significance levels are shown as *P value < .05. b(1) An illustrative Western blot picture of MMP-3 following SP600125 treatment (15 and 30 μM) after 3 and 24 h in RA-FLS. b(2) Normalized intensities were graphed (N = 3). Normalization was performed with MMP-3 bad intensity of untreated RA-FLS cell (3-h incubation). All values are expressed as the mean ± SEM (N = 3). The significance levels are shown as *P value < .05