Gene polymorphisms and expression levels of interleukin-6 and interleukin-10 in lumbar disc disease: a meta-analysis and immunohistochemical study

Table 1 Characteristics of the case-control studies included in meta-analysis

First author	Year	Country	Ethnicity	Age (year, mean ± sd)		Number cases/controls	Diagnostic criteria	Control group	Outcome measure (SNP genotyping)	HWE for controls	CASP
First author	Year	Country	Ethnicity	Cases	Controls	Number cases/controls	Diagnostic criteria	Control group	Outcome measure (SNP genotyping)	HWE for controls	CASP
Noponen-Hietala [10]	2005	Finland	Caucasian	44 ± 13	39 ± 13	155/179	MRI	NM	rs1800795, rs1800796, rs1800797, rs2069849, rs1800896	0.97	16
Eskola [11]	2010	Denmark	Caucasian	13.1 ± 0.4	13.1 ± 0.4	66/154	MRI	Patients without LDD	rs1800795, rs1800796, rs1800797, rs2069849, rs13306435	0.74	17
Kelempisioti [12]	2011	Finland	Caucasian	19	19	150/246	MRI	Patients without LDD	rs1800795, rs1800796, rs1800797, rs13306435	0.92	17
Lin [13]	2011	China	Asian	46.3 ± 8.4	46.5 ± 9.7	320/269	CT, MRI	NM	rs1800896, rs1800871	0.28	19
Huang [14]	2017	China	Asian	44.05 ± 9.02	41.85 ± 11.02	267/300	MRI	Patients without spine-related problems	rs1800795, rs1800796, rs1800896, rs1800871	0.93	18
Zhu [15]	2017	China	Asian	50.27 ± 12.53	50.65 ± 11.79	498/463	MRI	Patients without LDD	rs1800796	0.30	15

NM not mentioned, MRI magnetic resonance imaging, CT computerized tomography, CASP Critical Appraisal Skills Programme

ISSN: 1749-799X