Table 1 Characteristics of 16 studies applying alpha-defensin for meta-analysis
Study, year | Country | Participants (M/F) | Median age (range, years) | Study design | Detection method | Assay platform | Cutoff value | Gold standard |
|---|---|---|---|---|---|---|---|---|
Bingham et al. 2014 | USA | UA | UA | R | ELISA | Synovasure (CD Diagnostics) | 7.72 mg/L | MSIS |
Deirmengian et al. 2014-1 | USA | 70/79 | 65 (41–89) | P | ELISA | Hycult Biotech (Uden, the Netherlands) | 5.2 mg/L | MSIS |
Deirmengian et al. 2014-2 | USA | 44/51 | 66 (41–86) | P | ELISA | Hycult Biotech (Uden, The Netherlands) | 4.8 mg/L | MSIS |
Frangiamore SJ 2016 | USA | 53/63 | 63 (51–79) | P | ELISA | Synovasure (CD Diagnostics) | 5.2 mg/L | MSIS |
Kasparek et al. 2016 | USA | UA | 71 (41–91) | R | Lateral flow test | Synovasure (CD Diagnostics) | UA | MSIS |
Suda et al. 2017 | Germany | 17/11 | 67.7 (39–88) | P | Lateral flow test | Synovasure™ PJI Test (Zimmer, Warsaw, IN) | UA | MSIS |
Bonanzinga et al. 2017 | Germany | 66/90 | UA | P | Immunoassay | Synovasure (CD Diagnostics) | UA | MSIS |
Sigmund et al. 2017 | Austria | 22/28 | 65 (20–89) | P | Lateral flow test | Synovasure | UA | MSIS |
de Saint Vincent et al. 2018 | France | 24/15 | UA (35–78) | P | Lateral flow test | Synovasure™, (Zimmer, Warsaw, IN) | UA | MSIS |
Kelly et al. 2018 | USA | 21/18 | 64 (33–88) | R | Immunoassay | CD Diagnostics | UA | MSIS |
Scholten et al. 2018 | Netherlands | 22/15 | 66 (51–81) | P | Lateral flow test | Synovasure™, (Zimmer, Warsaw, IN) | UA | Culture |
Gehrke et al. 2018 | Germany | 77/114 | UA | P | Lateral flow test | Synovasure kit | UA | MSIS |
Sigmund et al. 2018 | Germany | 38/33 | 70 (41–85) | R | Lateral flow test/ELISA | Synovasure kit (Zimmer Biomet)/Synovasure™ (CD Diagnostics) | UA | MSIS/EBJIS/IDSA |
Riccio et al. 2018 | Italy | 30/45 | 68.7 (57–79) | R | Lateral flow test | Synovasure (CD Diagnostics) | UA | MSIS |
Stone et al. 2018 | USA | 78/105 | 65.7 (34–91) | P | Microarray | Synovasure (CD Diagnostics) | UA | MSIS |
Renz et al. 2018 | Germany | 61/106 | 70 (41–94) | P | Lateral flow test | Synovasure kit (Zimmer Biomet) | UA | MSIS |