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Fig. 2 | Journal of Orthopaedic Surgery and Research

Fig. 2

From: PI3K/Akt inhibitor partly decreases TNF-α-induced activation of fibroblast-like synoviocytes in osteoarthritis

Fig. 2

Effect of LY294002 on the migration and invasive capacity of OA FLS with stimulation of TNF-α. TNF-α increased migration (a) and invasive (b) capacity of OA FLS (p < 0.05). PI3K inhibitor, LY294002, could inhibit the invasive capacity of OA FLS induced by TNF-α (p < 0.05), but has little inhibitory effect on migration of OA FLS (p > 0.05). Five fields per filter were selected randomly and photographed. All experiments were repeated three times. Data are expressed as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X