Fig. 3
From: Emodin promotes fibroblast apoptosis and prevents epidural fibrosis through PERK pathway in rats
EMO prevented epidural fibrosis and inhibited fibroblast proliferation in rats. a Histological analysis images of the laminectomy operation areas treated with 100 mg/ml and 50 mg/ml EMO, and saline. The scar tissues were marked by asterisk, the magnification was × 40, and the fibrous tissue of the EMO group was significantly reduced in a concentration-dependent manner compared with the control group. These sections were stained by hematoxylin and eosin (HE). b The number of fibroblasts was reduced as the EMO concentration increased. The magnification was × 100. c We picked three fields to count fibroblast number from every section. *P < 0.05 versus the control group. d Histological analysis of the effect of EMO on collagen density in rat after laminectomy. With the increase of EMO concentration, the local collagen fiber density decreased