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Fig. 5 | Journal of Orthopaedic Surgery and Research

Fig. 5

From: A placebo-controlled study comparing the efficacy of intra-articular injections of hyaluronic acid and a novel hyaluronic acid-platelet-rich plasma conjugate in a canine model of osteoarthritis

Fig. 5

Microscopic assessments of the synovium and articular cartilage. Microscopic lesions of the synovium (a; H&E, scale bar = 100 μm) and articular cartilage (c; Safranin O, scale bar = 100 μm [upper low], scale bar = 20 μm [lower low]) in the affected knees of all experimental groups. Multiple cell layer (short arch) and villous hyperplasia (long arch) were observed in the synovium of the control and HA groups. Mild to moderate inflammatory cell infiltrates including small lymphoid follicles were identified in the control group. The articular cartilage at the superficial zone with an irregular surface (Arrowhead) was observed in the control group. The grade of proteoglycan staining (bidirectional arrows) was the lowest in the control group, followed by the HA group. The large cell clusters in chondrocyte (arrows with short body) were observed frequently compared with the HA and HA-PRP group. Comparison of the OARSI histopathologic scores in the affected synovium (b) and articular cartilage (d). *Significant differences (p < 0.05) compared to the groups treated with saline. #Significant difference (p < 0.05) between the HA group and the HA-PRP group

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X