Table 4 Association between haplotype of CHRNA5 regions and LDH in individuals
From: CHRNA5/CHRNA3 gene cluster is a risk factor for lumbar disc herniation: a case-control study
Analysis | Gene | SNP | Haplotype | OR (95% CI) | p value † |
|---|---|---|---|---|---|
Overall | CHRNA5 | rs667282|rs16969948|rs588765|rs6495306|rs17486278|rs680244|rs569207|rs692780 | TACAACCG | 1 | |
CACAACTG | 1.02 (0.83–1.24) | 0.857 | |||
TACACCCG | 0.79 (0.63–1.00) | 0.047 | |||
TGCAATCG | 1.02 (0.60–1.72) | 0.943 | |||
TATGATCC | 0.90 (0.70–1.15) | 0.387 | |||
TGCAATCC | 0.94 (0.39–2.29) | 0.892 | |||
≤ 50 | CHRNA5 | rs667282|rs16969948|rs588765|rs6495306|rs17486278|rs680244|rs569207|rs692780 | TACAACCG | 1 | |
CACAACTG | 1.15 (0.84–1.59) | 0.390 | |||
TGCAATCG | 0.56 (0.22–1.44) | 0.231 | |||
TACACCCG | 1.46 (1.01–2.13) | 0.047 | |||
TATGATCC | 0.84 (0.56–1.25) | 0.383 | |||
TGCAATCC | 0.9 (0.27–3.02) | 0.860 |