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Table 2 Summary of included randomized controlled trial

From: Is platelet-rich plasma an ideal biomaterial for arthroscopic rotator cuff repair? A systematic review and meta-analysis of randomized controlled trials

Authors/publish year

Population differences

Repair type

Outcomes measured

Relevant findings

Castricini et al. 2011 [25]

Included any full-thickness tear

Double row

Subjective: Constant scores

Imaging: MRI at 16 months

No difference in constant scores and retear rates between groups

Randelli et al. 2011 [31]

Included any full-thickness tear

Single row

Subjective: Constant, UCLA, SST

Imaging: MRI 12 months

Significant improvement in constant, UCLA, and SST in PRPþ group

No difference in outcomes at final follow-up

Gumina et al. 2012 [27]

Included only large tears

Excluded partial tears, massive tears, traumatic tears

Single row

Subjective: Constant, ST

Imaging: MRI at 12 months

Significantly increased constant score in the PRPþ group, but no difference in change from pre- to postoperatively

Weber et al. 2012 [35]

Included any arthroscopic rotator cuff repair

Single row

Subjective: ASES, UCLA, SST, VAS

Imaging: MRI at 12 months ROM

No difference in outcome scores or ROM between groups

No difference in retear rates between groups

Jo et al. 2013 [28]

Included only large tears (> 3 cm sagittal length)

Included 4 partial repairs

Double row

Subjective: ASES, CLA, Constant, SST, DASH, SPADI

Imaging: MRI or CTA at 9 months

No difference between the two groups on the VAS for pain, ROM, muscle strength, overall satisfaction, and function

The retear rate of the PRP group was significantly lower

Ruiz-Moneo et al. 2013 [33]

Included tendon retraction and fatty infiltration, smokers

Double row

Subjective: UCLA

Imaging: MRA at 12 months

No difference in UCLA scores between groups

No difference in retear rates between groups

Malavolta et al. 2014 [30]

Included only tears < 3 cm in sagittal length

Single row

Subjective: Constant, UCLA

Imaging: MRI at 3, 6, and 12 months

No differences in constant or UCLA scores between groups

No difference in retear rates between groups

Sánchez Márquez et al. 2011 [34]

Included only repairable large tears > 5

Excluded subscapularis tears

Single row

Subjective: Constant

Imaging: MRA at 12 months

No differences in constant or UCLA scores between groups

No difference in retear rates between groups

Rodeo et al. 2012 [32]

Included full-thickness tears, age > 40 years

Double row

Subjective: ASES, L’Insalata

Imaging: US at 12 weeks

No difference in outcome scores between groups

No difference in retear rates between groups

Flury et al. 2016 [26]

A complete rotator cuff tear

Double row

Subjective: Constant-Murley score, ASES, OSS

Imaging: MRI or US at 12 months

No significantly improved function at 3, 6, and 24 months after arthroscopic repair compared with control patients receiving ropivacaine

Holtby et al. 2016 [9]

Full-thickness and partial-thickness tear

Single row and double row

Subjective: VAS, CMS, ASES, ShortWORC

Imaging: MRI at 6 months

A short-term effect on perioperative pain

No significant impact on patient-oriented outcome measures or retear rate

Pandey et al. 2016 [10]

Medium-sized to large cuff tears

Single row

Subjective: VAS, CMS, ASES, UCLA

Imaging: US at 24 months

Retear in the PRP group was significantly lower, significant improvement in constant, UCLA score

No difference in ASES score

Jo et al. 2015 [29]

Medium to large rotator cuff tears

Double row

Subjective: Constant score, VAS, ASES, UCLA, SST, SPADI scores

Imaging: MRI at 12 months

A decreased retear rate of the supraspinatus, but not the speed of healing

No significantly improved function scores at and 12 months after arthroscopic