Table 1 The most enriched GO terms (BP) among proteins identified in exosomes of both groups
| Â | GO terms among proteins identified in exosomes (young) | GO terms among proteins identified in exosomes (aged) |
|---|---|---|
Protein | Establishment of protein localization to membrane (35) Protein peptidyl-prolyl isomerization (10) Chaperone-mediated protein complex assembly (4) Positive regulation of protein secretion (24) | Protein depolymerization (11) Cellular protein complex disassembly (13) Positive regulation of protein localization to nucleus (14) Protein nitrosylation (4) |
DNA | DNA conformation change (23/217) Telomere maintenance (15/113) | None |
Cell appendage morphogenesis | Lamellipodium organization (16) Ruffle organization (10) Membrane raft assembly (4) Podosome assembly (6) Regulation of cell junction assembly (12) | None |
Metabolism | Nitric oxide metabolic process (12) Regulation of nitric oxide biosynthetic process (12) Tricarboxylic acid metabolic process (8) | None |
Cellular transportation | Golgi vesicle transport (25) Energy coupled proton transmembrane transport (12) Positive regulation of protein transport(45) | None |
Cell clearance | Lysosome organization (5) Protein targeting to lysosome (5) | None |
Cell homeostasis | Regulation of pH (13) | Negative regulation of homeostatic process (18) |
Cellular response | Cellular response to peptide hormone stimulus (34) Response to parathyroid hormone (6) Response to angiotensin (7) Response to mineralocorticoid (10) | Acute-phase response (10) Response to fungus (7) Response to immobilization stress (7) Response to lipopolysaccharide (34) Killing by host of symbiont cells (4) |
Cell stress | Response to endoplasmic reticulum stress (23) | Respiratory burst (5) Cellular response to oxidative stress (23) |
Cell death | Negative regulation of apoptotic signaling pathway (15) | Regulation of intrinsic apoptotic signaling pathway in response to DNA damage (6) Cytolysis (6) Membrane invagination (9) |
Immunologic process | I-kappaB kinase/NF-kappaB signaling (24) | Activation of immune response (27) Positive regulation of leukocyte-mediated immunity (13) B cell-mediated immunity (16) Positive regulation of inflammatory response (13) Neutrophil migration (11) Granulocyte chemotaxis (12) Positive regulation of T cell activation (16) Leukocyte migration (29) Cell-cell recognition (9) Complement activation, lectin pathway (4) |
Cell-matrix adhesion | Regulation of cell-matrix adhesion (16) | None |
Skeletal system | Positive regulation of ossification (14) Osteoclast differentiation (5) | None |
Nervous system | Axon ensheathment (17) Peripheral nervous system axon regeneration (5) Glial cell differentiation (25) | Negative regulation of nervous system development (23) |
Other systems/tissue | Myeloid cell development (12) Regulation of muscle contraction (18) | Fibroblast proliferation (12) Renal system development (25) Regulation of coagulation (16) Smooth muscle cell proliferation (14) |