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Table 1 The most enriched GO terms (BP) among proteins identified in exosomes of both groups

From: Ageing characteristics of bone indicated by transcriptomic and exosomal proteomic analysis of cortical bone cells

  GO terms among proteins identified in exosomes (young) GO terms among proteins identified in exosomes (aged)
Protein Establishment of protein localization to membrane (35)
Protein peptidyl-prolyl isomerization (10)
Chaperone-mediated protein complex assembly (4)
Positive regulation of protein secretion (24)
Protein depolymerization (11)
Cellular protein complex disassembly (13)
Positive regulation of protein localization to nucleus (14)
Protein nitrosylation (4)
DNA DNA conformation change (23/217)
Telomere maintenance (15/113)
Cell appendage morphogenesis Lamellipodium organization (16)
Ruffle organization (10)
Membrane raft assembly (4)
Podosome assembly (6)
Regulation of cell junction assembly (12)
Metabolism Nitric oxide metabolic process (12)
Regulation of nitric oxide biosynthetic process (12)
Tricarboxylic acid metabolic process (8)
Cellular transportation Golgi vesicle transport (25)
Energy coupled proton transmembrane transport (12)
Positive regulation of protein transport(45)
Cell clearance Lysosome organization (5)
Protein targeting to lysosome (5)
Cell homeostasis Regulation of pH (13) Negative regulation of homeostatic process (18)
Cellular response Cellular response to peptide hormone stimulus (34)
Response to parathyroid hormone (6)
Response to angiotensin (7)
Response to mineralocorticoid (10)
Acute-phase response (10)
Response to fungus (7)
Response to immobilization stress (7)
Response to lipopolysaccharide (34)
Killing by host of symbiont cells (4)
Cell stress Response to endoplasmic reticulum stress (23) Respiratory burst (5)
Cellular response to oxidative stress (23)
Cell death Negative regulation of apoptotic signaling pathway (15) Regulation of intrinsic apoptotic signaling pathway in response to DNA damage (6)
Cytolysis (6)
Membrane invagination (9)
Immunologic process I-kappaB kinase/NF-kappaB signaling (24) Activation of immune response (27)
Positive regulation of leukocyte-mediated immunity (13)
B cell-mediated immunity (16)
Positive regulation of inflammatory response (13)
Neutrophil migration (11)
Granulocyte chemotaxis (12)
Positive regulation of T cell activation (16)
Leukocyte migration (29)
Cell-cell recognition (9)
Complement activation, lectin pathway (4)
Cell-matrix adhesion Regulation of cell-matrix adhesion (16) None
Skeletal system Positive regulation of ossification (14)
Osteoclast differentiation (5)
Nervous system Axon ensheathment (17)
Peripheral nervous system axon regeneration (5)
Glial cell differentiation (25)
Negative regulation of nervous system development (23)
Other systems/tissue Myeloid cell development (12)
Regulation of muscle contraction (18)
Fibroblast proliferation (12)
Renal system development (25)
Regulation of coagulation (16)
Smooth muscle cell proliferation (14)
  1. The numbers in parentheses are the counts of proteins annotated for each GO term