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Table 3 Univariate and multivariate logistic regression analyses of variables potentially associated with in-hospital mortality in NF

From: Lactate on emergency department arrival as a predictor of in-hospital mortality in necrotizing fasciitis: a retrospective study

 

Univariate binary logistic regression

Multivariate logistic regression

OR (95% CI)

P value

OR (95% CI)

P value

Age

1.02 (0.96–1.08)

0.542

1.06 (0.96–1.16)

0.249

SOFA score

1.28 (1.06–1.51)

< 0.001

1.15 (1.11–1.20)

< 0.001e

Episode of hypotension

1.03 (1.01–1.05)

0.001

1.11 (0.63–1.97)

0.715

Episode of SpO2 < 90%

1.58 (1.07–2.33)

0.325

1.14 (1.02–1.18)

0.459

Acidosis

1.05 (1.01–1.08)

< 0.001

1.03 (0.94–1.12)

0.217

Coagulopathy

1.01 (1.00–1.01)

0.001

1.02 (1.01–1.08)

0.428

Thrombocytopenia

1.03 (0.98–1.08)

0.556

1.01 (0.93–1.03)

0.829

Anemia

1.05 (1.02–1.10)

0.065

0.99 (0.98–1.01)

0.913

Hypothermia

1.01 (1.00–1.01)

0.213

1.03 (0.98–1.07)

0.541

Hyperthermia

1.12 (1.02–1.15)

0.968

1.02 (1.01–1.12)

0.280

Blood lactate

1.35 (1.30–1.46)

< 0.001a

1.17 (1.07–1.29)

< 0.001b, c

Serum glucose

1.09 (1.01–1.23)

< 0.01

1.94 (0.76–4.75)

0.580

Serum albumin

0.86 (0.83–0.89)

< 0.001d

0.92 (0.88–0.96)

< 0.001d

Serum CRP

1.11 (1.08–1.13)

< 0.001

1.24 (1.18–3.27)

0.086

Serum creatinine

1.01 (1.00–1.01)

< 0.001

1.12 (0.89–2.35)

0.306

Diabetes mellitus

1.05 (1.02–1.06)

0.133

1.18 (1.02–1.29)

0.102

Liver cirrhosis

1.02 (1.00–1.03)

0.506

1.05 (1.01–1.09)

0.020

Chronic kidney disease

1.02 (1.00–1.02)

< 0.01

1.14 (1.05–1.18)

0.061

  1. The P value of the Hosmer-Lemeshow goodness-of-fit test for the multivariate logistic regression model was 0.611
  2. CI confidence interval, CRP C-reactive protein, DBP diastolic blood pressure, OR odds ratio, SBP systolic blood pressure, SOFA sequential organ failure assessment
  3. aThe association of blood lactate with in-hospital mortality remained significant after adjustment for age and SOFA score (OR = 1.23; 95% CI, 1.19–1.35; P < 0.001)
  4. bThe association of the blood lactate level with in-hospital mortality remained significant after adjustment for serum albumin and SOFA score (OR = 1.15; 95% CI, 1.05–1.32; P < 0.001)
  5. cOdds ratio represents the increase in risk per 1 mmol/l increase in lactate concentration
  6. dOdds ratio per 1 g/dl increase in albumin level
  7. eOdds ratio per 1-point increase in SOFA score