Clinicopathological and prognostic value of hypoxia-inducible factor-1α in patients with bone tumor: a systematic review and meta-analysis

Table 2 The analysis for HIF-1α and the clinicopathological features of patients with bone tumor

Clinicopathological features	Number of studies	Number of case (n)	Number of HIF-1α + (n)	Pooled data			Test for heterogeneity
Clinicopathological features	Number of studies	Number of case (n)	Number of HIF-1α + (n)	RR	95% CI	P value	χ ²	P value	I² (%)
Gender (male vs. female)	13	832	500	0.93	0.83–1.04	0.179	12.97	0.371	7.5
Age (year) (≤ 20 vs. > 20)	6	481	303	1.19	1.00–1.41	0.055	8.72	0.121	42.7
Size (cm) (≥ 5.0 vs. < 5)	7	378	222	1.19	0.99–1.44	0.069	6.86	0.334	12.6
Differentiation (poor vs. well/moderate)	8	272	174	1.56	1.00–2.43	0.049	28.33	< 0.001	75.3
Clinical stage (II/III vs. I)	6	396	207	1.75	1.25–2.45	0.001	8.89	0.113	43.8
Metastasis (yes vs. no)	14	870	503	1.78	1.58–2.00	< 0.001	24.91	0.024	47.8

HIF-1α + hypoxia-inducible factor-1α expression, RR risk ratio, CI confidence interval

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