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Table 1 Concentration of cytokines in plasma following trauma at 24 and 72 h post-trauma

From: Burn and thoracic trauma alters fracture healing, systemic inflammation, and leukocyte kinetics in a rat model of polytrauma

Analyte

24 h osteotomy

24 h polytrauma

p value

72 h osteotomy

72 h polytrauma

p value

G-CSF

201.00 ± 15.73

195.4 ± 14.26

0.9610

110.80 ± 22.75

67.20 ± 0.86

0.1260

Glucagon

88.76 ± 16.76

90.73 ± 7.01

0.9912

62.80 ± 3.03

105.28 ± 13.20

0.0556*

GM-CSF

53.72 ± 12.70

54.46 ± 8.679

0.9979

54.46 ± 8.68

44.53 ± 3.72

0.9777

GRO/KC

9.51 ± 1.94

3.50 ± 0.48

0.0102**

3.5 ± 0.78

1.74 ± 0.10

0.5746

IFN-γ

68.74 ± 5.82

61.61 ± 15.00

0.8757

38.38 ± 13.74

15.86 ± 4.46

0.2944

IL-1a

7.53 ± 4.28

6.39 ± 3.72

0.9597

8.33 ± 1.76

1.55 ± 0.00

0.2807

IL-1b

5.60 ± 0.47

5.69 ± 0.55

0.9896

6.24 ± 0.37

6.05 ± 0.55

0.9572

IL-2

22.28 ± 4.31

11.85 ± 1.64

0.0537*

9.40 ± 0.71

9.38 ± 2.24

0.9999

IL-4

143.28 ± 41.07

83.59 ± 34.57

0.3508

123.67 ± 18.64

45.62 ± 20.30

0.2689

IL-5

1.42 ± 0.27

2.33 ± 1.00

0.5264

2.49 ± 0.43

1.12 ± 0.19

0.2197

IL-6

104.12 ± 26.50

59.21 ± 3.63

0.1658

115.54 ± 14.72

53.27 ± 8.62

0.0330*

IL-7

59.25 ± 16.33

124.25 ± 14.36

0.0177*

ND

ND

N/A

IL-10

13.50 ± 3.15

4.86 ± 1.18

0.0240*

4.86 ± 1.06

2.14 ± 0.09

0.6749

IL-12p40

18.05 ± 2.82

38.22 ± 3.46

0.0001**

13.45 ± 0.74

10.00 ± 2.21

0.5740

IL-13

17.75 ± 1.93

10.81 ± 0.00

0.8534

26.74 ± 10.42

12.16 ± 3.77

0.1791

IL-18

11.40 ± 2.27

13.30 ± 3.04

0.7768

10.45 1.33

4.7 ± 1.07

0.1320

Leptin

604.29 ± 68.36

865.91 ± 310.39

0.5166

926.16 ± 102.66

416.43 ± 100.90

0.1077

M-CSF

2.38 ± 0.45

6.538 ± 2.645

0.7629

14.67 ± 8.054

2.47 ± .3432

0.1601

MIP-1a

5.03 ± 0.30

3.64 ± 0.30

0.0143*

5.03 ± 0.46

3.44 ± 0.12

0.0056**

MIP-2

4.25 ± 0.54

5.56 ± 1.69

0.6270

4.00 ± 1.02

2.57 ± 0.16

0.6413

MIP-3a

1.09 ± 0.14

2.00 ± 0.42

0.0405*

0.64 ± 0.22

0.64 ± 0.06

0.9995

PAI-1

13.01 ± 3.07

9.05 ± 2.13

0.3339

4.35 ± 1.00

7.29 ± 1.15

0.5350

TNF-α

69.02 ± 11.08

40.29 ± 3.67

0.7202

140.25 ± 53.69

35.19 ± 3.26

0.0313*

VEGF

65.41 ± 13.92

51.24 ± 8.67

0.6189

58.00 ± 11.73

44.91 ± 9.34

0.7323

MCP-1

17.50 ± 5.14

4.30 ± 1.00

0.1170

ND

ND

N/A

  1. Plasma concentrations of analytes were assessed using a Bio-Plex Multiplex Immunoassay. Values are reported as picogram/milliliter in two experimental cohorts, osteotomy and polytrauma at 24 and 72 h post-trauma. Values are reported as mean ± SEM. Statistically significant differences between osteotomy and polytrauma cohorts are indicated as follows: *p < 0.05, **p < 0.01; n = 5/group/time point. Analytes which were non-detectable are designated as ND
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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X