Whole-genome sequencing reveals novel genes in ossification of the posterior longitudinal ligament of the thoracic spine in the Chinese population

Table 4 Previously reported genes and microRNAs related to OPLL

Year	First author	Country	Gene	Chromosome	Location
2002	Ogata	Japanese	IL-1β	2q14	Spine
2018	Wang	Chinese	IL17RC	3p25.3 to 3p24.1	Thoracic
1999	Numasawa	Japanese	RXRB	6p21	Spine
1998	Koga	Japanese	COL11A2	6p21	Spine
2010	Liu	Chinese	RUNX2	6p21	Spine
1999	Nakamura	Japanese	NPPS	6q22-q23	Spine
2002	Ogata	Japanese	ESR1	6q25	Spine
2016	Nakajima	Japanese	Rspo2	8q23.1	Spine
2014	Wei	Chinese	PTCH1	9q22.23	Cervical
2011	Kim	Korean	IL15RA	10p15	Spine
2012	Ren	Chinese	BMP9	10q11.22	Cervical
2014	Wei	Chinese	COL17A1	10q24.3-10q25.1	Cervical
2008	Kobashi	Japanese	VDR	12q13	Spine
2006	Horikoshi	Japanese	TGFβ3	14q24	Spine
2002	Furushima	Japanese	BMP4	14q22	Spine
2001	Kamiya	Japanese	TGFβ1	19q13	Cervical
2008	Wang	Chinese	BMP2	20p12.3	Cervical
2003	Tanaka	Japanese	COL6A1	21q22.3	Spine
2018	Wang	Chinese	COL6A1	21q22.3	Thoracic
2014	Chon	Korean	BID	22q11	Cervical
2016	Lim	Korean	miR-146a		Cervical
			miR-149		Cervical
			miR-196a2		Cervical
			miR-499		Cervical
2016	Xu	Chinese	miR-10a-5p		Cervical
			miR-563		Cervical
			miR-885-5p		Cervical
Present	Liang	Chinese	COL6A6	3q22.1	Thoracic
			COL9A1	6q13	Thoracic
			TLR1	4p14	Thoracic

ISSN: 1749-799X