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Table 3 Summary of the results

From: In vivo cartilage tissue engineering

  MIV MIV + collagenase MIV + collagenase + GF MACI Control
Subject No 1 2 3 AVG10 5 6 7 8 AVG 9 11 12 AVG 14 15 16 AVG 17 18 19 AVG
Macroscopic score 8 7 4 6 6 5 5 5 5 3 5 3 4 7 5 4 5 3 3 3 3
Histologic score: lesion1 10 8 8 9 6 8 7 7 7 8 8 7 8 10 9 8 9 2 2 2 2
Histologic score: intact2 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24
Histologic score: patella3 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24
GAG lesion4 11.5 11.7 11.3 11.50 11.0 12.2 11.6 10.9 11.43 10.8 9.9 7.6 9.43 11.8 12.1 11.9 11.93 10.4 10.5 10.4 10.43
GAG intact5 9.9 10.7 10.1 10.23 9.5 10.0 12.6 10.9 10.75 9.8 11.3 9.7 10.27 10.2 10.3 9.9 10.13 11.7 11.4 11.8 11.63
GAG patella6 11.0 10.9 10.8 10.90 11.5 11.9 10.8 11.0 11.30 11.8 10.6 11.9 11.43 11.6 11.0 11.8 11.47 11.5 11.4 11.4 11.43
Collagen type II: lesion7 22.5 34.7 20.6 25.93 9.2 10.0 8.6 8.0 8.95 7.5 6.7 6.4 6.87 41.8 40.0 41.5 41.10 2.5 2.4 2.5 2.47
Collagen type II: intact8 9.0 9.3 7.3 8.53 12.6 6.7 6.7 8.9 8.73 11.3 6.3 8.8 8.80 6.7 6.2 9.4 7.43 8.3 8.5 8.0 8.27
Collagen type II: patella9 8.4 7.9 7.8 8.03 8.9 9.2 7.7 8.6 8.6 7.9 8.6 9.1 8.53 8. 7.8 8.2 8.30 8.5 8.6 8.8 8.63
  1. 1Histomorphometric score of the experimental lesion area
  2. 2Histomorphometric score of the intact cartilage obtained from the contralateral knee
  3. 3Histomorphometric score of the patellar cartilage obtained from the ipsilateral knee
  4. 4Experimental lesion area tissue glycosaminoglycan concentration (μg/mL)
  5. 5Intact cartilage obtained from the contralateral knee tissue glycosaminoglycan concentration (μg/mL)
  6. 6Patellar cartilage obtained from the ipsilateral knee tissue glycosaminoglycan concentration (μg/mL)
  7. 7Experimental lesion area tissue type II collagen concentration (ng/mL)
  8. 8Intact cartilage obtained from the contralateral knee tissue type II collagen concentration (ng/mL)
  9. 9Patellar cartilage obtained from the ipsilateral knee tissue type II collagen concentration (ng/mL)
  10. 10Group average value