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Table 2 Modified O’Driscoll Scoring System [36, 37]

From: In vivo cartilage tissue engineering

Category

Score

1. Nature of predominant tissue

 Cellular morphology

  Hyaline articular cartilage

4

  Partially differentiated mesenchyme

2

  Fibrous tissue or bone

0

2. Structural properties

 Surface integrity

  Smooth and in tact

3

  Superficial horizontal lamination

2

  Fissures: 25–100% of thickness

1

  Significant disruption, including fibrillation

0

 Structural integrity

  Normal

2

  Slight disruption, including cysts

1

  Significant disruption

0

 Thickness

  100% of normal surrounding cartilage

2

  50–100% of normal cartilage

1

  0–50% of normal cartilage

0

 Bonding at adjacent cartilage

  Bonded at both ends

2

  Bonded at one end or partially at both

1

  Not bonded

0

3. Independence from cellular changes of degeneration

 Hypocellularity

  Normal cellularity

3

  Mild hypocellularity

2

  Moderate hypocellularity

1

  Severe hypocellularity

0

 Chondrocyte grouping

  No grouping

2

  Less than 25% of cells

1

  25–100% of cells

0

4. Independence from degenerative changes of adjacent cartilage

 Cellular properties

  Normal cellularity, no grouping

3

  Normal cellularity, mild grouping

2

  Mild or moderate hypocellularity

1

  Severe hypocellularity

0

 Fibrillation

  No fibrillation

3

  Less than 25% of the thickness of cartilage

2

  25–50% of the thickness of cartilage

1

  More than 50% of the thickness of cartilage

0