Table 2 Characteristics of included studies
Study | Operation | Cases (A/C) | Mean age (A/C) | Gender (F) | Dosage | Prophylactic anticoagulant | Transfusion trigger |
|---|---|---|---|---|---|---|---|
Camarasa et al. 2006 | TKA | 32/60 | 73/72 | 28/48 | 100 mg/kg administered intravenously in 30 min (before tourniquet release) + 3 g for 3 h following first dose | LMWH | Hb < 8 g/dl or 10 g/dl with clinical symptoms |
Churchill et al. 2017 | TKA | 820/1492 | 63.9/63.9 | 527/956 | 5 g (BW < 50 kg); 10 g (BW > 50 kg) administered intravenously near the time of tourniquet release | Surgeon’s discretion | NS |
Churchill et al. 2016 (THA) | THA | 911/643 | 65.1/65.4 | 392/377 | 5 g (BW < 50 kg); 10 g (BW > 50 kg) administered intravenously near the time of incision | Surgeon’s discretion | Surgeon’s discretion |
Churchill et al. 2016 (TKA) | TKA | 25/25 | 65.2/66.6 | 21/15 | 10 g administered intravenously over 10 min and was completely infused before tourniquet deflation | Warfarin | Hb < 7 g/dl or 9 g/dl with clinical symptoms |
Harley et al. 2002 | THA | 26/29 | 69/69 | 16/18 | 150 mg/kg administered intravenously over 20 min on the patient’s arrival in the operating room + 12.5 mg/kg/h for an additional 5 h | Heparin | Hb < 80 g/L or HCT < 0.24 or patients having anemia symptoms |
Hobbs et al. 2017 | THA and TKA | 184/185 | 62.1/63.1 | 14/14 | 5 g administered intravenously over 20 min before incision + 5 g again during closure | Asprin, LMWH | Surgeon’s discretion |
Ray et al. 2005 | THA | 15/15 | 72/69 | NS | 10 g administered intravenously over 30 min after the induction of anesthesia + 5 g over 3 h | Aspirin | NS |