Table 3 Meta-analysis for the ADAM2 rs3740199 polymorphism and knee OA risk
From: Genetic effects of rs3740199 polymorphism in ADAM12 gene on knee osteoarthritis: a meta-analysis
Population | Comparison (N a) | Test of association | Test of heterogeneity | ||
|---|---|---|---|---|---|
OR (95% CI) | P b | P c | I 2 (%) | ||
Overall | C vs. G (12) | 0.983 (0.910–1.061) | 0.657 | 0.490 | 0.0 |
CC vs. GG (6) | 1.033 (0.851–1.255) | 0.740 | 0.681 | 0.0 | |
CG vs. GG (6) | 1.030 (0.877–1.209) | 0.721 | 0.770 | 0.0 | |
CC/CG vs. GG (6) | 1.031 (0.886–1.201) | 0.690 | 0.768 | 0.0 | |
CC vs. CG/GG (6) | 1.017 (0.868–1.190) | 0.837 | 0.364 | 8.1 | |
Ethnicity | |||||
Asian | C vs. G (4) | 1.020 (0.924–1.127) | 0.689 | 0.398 | 0.0 |
CC vs. GG (4) | 1.040 (0.850–1.272) | 0.703 | 0.390 | 0.4 | |
CG vs. GG (4) | 1.035 (0.878–1.221) | 0.681 | 0.709 | 0.0 | |
CC/CG vs. GG (4) | 1.036 (0.887–1.211) | 0.656 | 0.502 | 0.0 | |
CC vs. CG/GG (4) | 1.017 (0.858–1.207) | 0.843 | 0.642 | 0.0 | |
European | C vs. G (8) | 0.930 (0.825–1.049) | 0.239 | 0.538 | 0.0 |
CC vs. GG (2) | 0.950 (0.453–1.992) | 0.891 | 0.809 | 0.0 | |
CG vs. GG (2) | 0.927 (0.446–1.930) | 0.840 | 0.301 | 6.6 | |
CC/CG vs. GG (2) | 0.940 (0.465–1.901) | 0.864 | 0.713 | 0.0 | |
CC vs. CG/GG (2) | 0.998 (0.445–2.237) | 0.996 | 0.052 | 73.4 | |