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Table 1 Trials characteristics

From: Comparison of local infiltration analgesia and sciatic nerve block for pain control after total knee arthroplasty: a systematic review and meta-analysis

Studies Reference type Cases Mean age Female patient Anesthesia Drug dose of FNB Drug dose of SNB Drug dose of LIA Concomitant Pain Follow-up
(SNB/LIA) (SNB/LIA) (SNB/LIA)
Tanikawa 2014 [11] RCT 23/23 72/71 19/20 General anesthesia 20 ml of 0.375% ropivacaine 20 ml of 0.375% ropivacaine 200 mg of ropivacaine and 0.5 ml of adrenaline IV ketorolac 30 mg, ketoprofen 100 mg, or diclofenac 75 mg 3 months
Gi 2014 [13] RCT 24/25 78/77 21/24 General anesthesia 20 ml 0.375% ropivacaine 20 ml 0.375% ropivacaine 60 ml 0.5% ropivacaine with 0.3 mg epinephrine 400 mg celecoxib, 20 mg oxycontin, and a 6 mg scopolamine patch topically 1 month
Safa 2014 [12] RCT 33/32 61/61 18/15 Spinal anesthesia 20 mL of 0.5% ropivacaine 20 mL of 0.5% ropivacaine 50 mL of 0.2% ropivacaine Celecoxib 200 mg, gabapentin 200 mg and acetaminophen 1 g 1.5–3 months
Nagafuchi 2015 [14] RCT 17/16 72/73 15/13 General anesthesia 20 mL of 0.375% ropivacaine 20 ml of 0.375% ropivacaine 100 mL of 0.2% ropivacaine Celecoxib 200 mg, gabapentin 200 mg and acetaminophen 1 g 1 months
Cip 2016 [15] Non-RCT 16/18 73.4/71.8 12/11 Spinal or general anesthesia 0.2% ropivacaine (4 ml/h) 20 ml ropivacaine 0.2% 0.33% ropivacaine (5 mL/h) Celecoxib and Oxycodone NS
Aikawa 2016 [16] Non-RCT 23/23 72/71 19/20 general anesthesia 20 ml 0.375% ropivacaine 20 ml 0.375% ropivacaine 20 mL of 0.375% levobupivacaine NS 6 months
  1. SNB sciatic nerve block, LIA local infiltration of analgesia, IV intravenous, NS not stated