Fig. 2

ReactomeFI analysis of iTRAQ data from serum samples. a Workflow pathway enrichment analysis iTRAQ data. All proteins quantified in the iTRAQ experiment, regardless of the disease state, were uploaded in cytoscape via ReactomeFI application. Genes were clustered based on pathway and sub-network annotations. A pathway enrichment analysis indicated that 90 pathways were enriched within the proteomic space of serum samples. b Reactome analysis serum samples. Proteins were clustered using ReactomeFI, and 13 major modules were identified. A pathway enrichment analysis was completed for each module using an FDR >0.01