Skip to main content

Table 2 Characteristics of the five trials selected showing general intervention information

From: Is combined use of intravenous and intraarticular tranexamic acid superior to intravenous or intraarticular tranexamic acid alone in total knee arthroplasty? A meta-analysis of randomized controlled trials

Study Combine IA IV Transfusion criteria Pneumatic tourniquet Thromboprophylaxis DVT screening method
IA IV
Huang ZY 1.5 g TXA 50 mL NS after implantation of the components 1.5 g TXA before inflation of the tourniquet   3 g TXA before inflation of the tourniquet 7.0 g/dL < HB < 10 g/dL + symptomatic anemia HB < 7.0 g/dL Yes LMWH Doppler ultrasound
Jain NP 2 g TXA 30 mL NS 5 min before closure of arthrotomy 15 mg/kg TXA
30 min before skin incision 10 mg/kg TXA 3 and 6 h after surgery
  15 mg/kg TXA 30 min before skin incision
10 mg/kg TXA 3 and 6 h after surgery
7.0 g/dL < HB < 8.0 g/dL + symptoms HB < 7.0 g/dL No Aspirin Ultrasonographic + clinical symptom
Lin SY 1 g TXA after joint capsule closure 1 g TXA 15 min before skin incision 1 g TXA 20 mL NS after joint capsule closure   HB < 8.0 g/dL
HB < 9.0 g/dL +symptoms
Yes Rivaroxaban Clinical symptom
Nielsen CS 3 g TXA 100 mL NS after closure of the capsule 1 g TXA preoperative   1 g of TXA HB < 7.5 g/dL
HB < 10 g/dL +symptoms
postoperative Hb level was reduced >25% + symptoms
No Rivaroxaban NS
Song EK 1.5 g TXA 50 mL NS after wound close 10 mg/kg 20 min before tourniquet application
10 mg/kg 3 h after the second dose
1.5 g TXA 50 mL NS after wound closure 10 mg/kg 20 min before tourniquet application
10 mg/kg 15 min before deflation of the tourniquet
10 mg/kg 3 h after the second dose
HB < 8 g/dL Yes LMWH Clinical symptom + Doppler ultrasonography and CT angiography