Skip to main content

Table 6 Univariate and multivariate odds ratio of PTE and DVT in patients who underwent TKA, THA, and HFS

From: Incidence of venous thromboembolism and bleeding events in patients with lower extremity orthopedic surgery: a retrospective analysis of a Japanese healthcare database

  Total no. of patients PTE no. (%) PTE DVT no. (%) DVT
Risk factors Univariate model Multivariate model Univariate model Multivariate model
  Odds ratio (95% CI) Odds ratio (95% CI) Odds ratio (95% CI) Odds ratio (95% CI)
Type of surgery        
 HFS 20,986 29 (0.1) 1 93 (0.4) 1 1
 TKA 5023 8 (0.2) 1.1 (0.5–2.5) 65 (1.3) 2.9 (2.1–4.0)*** 2.7 (1.9–2.7)***
 THA 3856 6 (0.2) 1.1 (0.5–2.7) 33 (0.9) 1.9 (1.3–2.9)** 2.1 (1.4–3.2)***
Sex        
 Male 6378 3 (0.0) 1 1 22 (0.3) 1 1
 Female 23,487 40 (0.2) 3.6 (1.1–11.7)* 3.5 (1.1–11.3)* 169 (0.7) 2.1 (1.3–3.3)** 1.9 (1.2–2.9)**
History of VTE        
 No 29,816 42 (0.1) 1 1 187 (0.6) 1 1
 Yes 49 1 (2.0) 14.8 (2.0–109.5)** 9.8 (1.2–77.5)* 4 (8.2) 14.1 (5.0–39.6)*** 11.4 (4.0–32.3)***
Thrombophilia        
 No 29,582 41 (0.1) 1 1 184 (0.6) 1 1
 Yes 283 2 (0.7) 5.1 (1.2–21.3)* 4.7 (1.1–19.8)* 7 (2.5) 4.1 (1.9–8.7)*** 3.0 (1.4–6.4)**
Elderly (age)        
 <65 3941 5 (0.1) 1 14 (0.4) 1 1
 65 to 75 5458 9 (0.2) 1.3 (0.4–3.9) 54 (1.0) 2.8 (1.6–5.1)*** 2.5 (1.4–4.5)**
 >75 year 20,466 29 (0.1) 1.1 (0.4–2.9) 123 (0.6) 1.7 (1.0–3.0) 2.1 (1.1–3.7)*
Antipsychotic drug        
 No 26,958 42 (0.2) 1 182 (0.7) 1
 Yes 2907 1 (0.0) 0.2 (0.0–1.6) 9 (0.3) 0.5 (0.2–0.9)*
Obesity (body mass index )        
 <18.5 4971 4 (0.1) 1 20 (0.4) 1
 18.5 to 25 14,331 20 (0.1) 1.7 (0.6–5.1) 87 (0.6) 1.5 (0.9–2.5)
25 5369 13 (0.2) 3.0 (1.0–9.3) 54 (1.0) 2.5 (1.5–4.2)***
 Unknown 5194 6 (0.1) 1.4 (0.4–5.1) 30 (0.6) 1.4 (0.8–2.5)
Varicose veins of lower extremity        
 No 29,767 41 (0.1) 1 1 189 (0.6) 1
 Yes 98 2 (2.0) 15.1 (3.6–63.3)*** 10.9 (2.5–47.5)** 2 (2.0) 3.3 (0.8–13.3)
  1. Abbreviations are the same as Tables 1 and 4.
  2. *p < 0.05; **p < 0.01; ***p < 0.001
  3. Risk factors with statistical significance are shown. The following factors without statistical significance are not listed: lower limbs paralysis, lower limbs casting, congestive heart failure, respiratory failure, malignant disease, central venous catheter, cancer chemotherapy, pregnancy, severe infections, and estrogen replacement therapy