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Table 6 Univariate and multivariate odds ratio of PTE and DVT in patients who underwent TKA, THA, and HFS

From: Incidence of venous thromboembolism and bleeding events in patients with lower extremity orthopedic surgery: a retrospective analysis of a Japanese healthcare database

 

Total no. of patients

PTE no. (%)

PTE

DVT no. (%)

DVT

Risk factors†

Univariate model

Multivariate model

Univariate model

Multivariate model

 

Odds ratio (95% CI)

Odds ratio (95% CI)

Odds ratio (95% CI)

Odds ratio (95% CI)

Type of surgery

       

 HFS

20,986

29 (0.1)

1

–

93 (0.4)

1

1

 TKA

5023

8 (0.2)

1.1 (0.5–2.5)

–

65 (1.3)

2.9 (2.1–4.0)***

2.7 (1.9–2.7)***

 THA

3856

6 (0.2)

1.1 (0.5–2.7)

–

33 (0.9)

1.9 (1.3–2.9)**

2.1 (1.4–3.2)***

Sex

       

 Male

6378

3 (0.0)

1

1

22 (0.3)

1

1

 Female

23,487

40 (0.2)

3.6 (1.1–11.7)*

3.5 (1.1–11.3)*

169 (0.7)

2.1 (1.3–3.3)**

1.9 (1.2–2.9)**

History of VTE

       

 No

29,816

42 (0.1)

1

1

187 (0.6)

1

1

 Yes

49

1 (2.0)

14.8 (2.0–109.5)**

9.8 (1.2–77.5)*

4 (8.2)

14.1 (5.0–39.6)***

11.4 (4.0–32.3)***

Thrombophilia

       

 No

29,582

41 (0.1)

1

1

184 (0.6)

1

1

 Yes

283

2 (0.7)

5.1 (1.2–21.3)*

4.7 (1.1–19.8)*

7 (2.5)

4.1 (1.9–8.7)***

3.0 (1.4–6.4)**

Elderly (age)

       

 <65

3941

5 (0.1)

1

–

14 (0.4)

1

1

 65 to 75

5458

9 (0.2)

1.3 (0.4–3.9)

–

54 (1.0)

2.8 (1.6–5.1)***

2.5 (1.4–4.5)**

 >75 year

20,466

29 (0.1)

1.1 (0.4–2.9)

–

123 (0.6)

1.7 (1.0–3.0)

2.1 (1.1–3.7)*

Antipsychotic drug

       

 No

26,958

42 (0.2)

1

–

182 (0.7)

1

–

 Yes

2907

1 (0.0)

0.2 (0.0–1.6)

–

9 (0.3)

0.5 (0.2–0.9)*

–

Obesity (body mass index )

       

 <18.5

4971

4 (0.1)

1

–

20 (0.4)

1

–

 18.5 to 25

14,331

20 (0.1)

1.7 (0.6–5.1)

–

87 (0.6)

1.5 (0.9–2.5)

–

 ≧25

5369

13 (0.2)

3.0 (1.0–9.3)

–

54 (1.0)

2.5 (1.5–4.2)***

–

 Unknown

5194

6 (0.1)

1.4 (0.4–5.1)

–

30 (0.6)

1.4 (0.8–2.5)

–

Varicose veins of lower extremity

       

 No

29,767

41 (0.1)

1

1

189 (0.6)

1

–

 Yes

98

2 (2.0)

15.1 (3.6–63.3)***

10.9 (2.5–47.5)**

2 (2.0)

3.3 (0.8–13.3)

–

  1. Abbreviations are the same as Tables 1 and 4.
  2. *p < 0.05; **p < 0.01; ***p < 0.001
  3. †Risk factors with statistical significance are shown. The following factors without statistical significance are not listed: lower limbs paralysis, lower limbs casting, congestive heart failure, respiratory failure, malignant disease, central venous catheter, cancer chemotherapy, pregnancy, severe infections, and estrogen replacement therapy
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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X