Fig. 2
From: Autologous bone grafts with MSCs or FGF-2 accelerate bone union in large bone defects
Plain radiogram in each group. Autologous bone grafting in a rat model was performed by transplanting the mid-section of the femoral shaft from the right femur to the left, and vice versa, with no further treatment (group A) or in conjunction with FGF-2 at 20 μg/20 μL (group B) or MSCs (1 × 106 cells in 20 μL). In group A, there was good callus formation but no callus around the autologous bone graft. In group B, there was good callus formation but no bridging. In contrast in group C, there was good callus formation and bridging at 6 weeks, while by 12 weeks, the callus volume was reduced to less than that in groups A or B, but bone union was achieved at 12 weeks